What the mitochondria see

Abstract

High-Ca(2+) microdomains at ER-mitochondrial junctions have been presumed to exist. Csordás et al. (2010) and Giacomello et al. (2010) report the Ca(2+) dynamics at the outer mitochondrial membrane surface in response to IP(3)-mediated Ca(2+) release and store-mediated Ca(2+) influx with several expected and some unexpected findings