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Response rates to medical treatments and long-term clinical outcomes of nonsurgical patients with intestinal Behçet disease

Authors
 Moon Jae Chung  ;  Jae Hee Cheon  ;  Seung Up Kim  ;  Jae Jun Park  ;  Tae Il Kim  ;  Nam Kyu Kim  ;  Won Ho Kim 
Citation
 JOURNAL OF CLINICAL GASTROENTEROLOGY, Vol.44(6) : 116-122, 2010 
Journal Title
 JOURNAL OF CLINICAL GASTROENTEROLOGY 
ISSN
 0192-0790 
Issue Date
2010
MeSH
Adolescent ; Adrenal Cortex Hormones/administration & dosage ; Adult ; Aged ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Azathioprine/administration & dosage ; Behcet Syndrome*/drug therapy ; Behcet Syndrome*/pathology ; Behcet Syndrome*/prevention & control ; Behcet Syndrome*/surgery ; Colchicine/administration & dosage ; Drug Therapy, Combination ; Female ; Humans ; Immunosuppressive Agents/administration & dosage ; Intestinal Diseases*/drug therapy ; Intestinal Diseases*/pathology ; Intestinal Diseases*/surgery ; Korea ; Male ; Mesalamine/administration & dosage ; Middle Aged ; Prognosis ; Recurrence ; Risk Factors ; Time Factors ; Treatment Outcome ; Ulcer*/drug therapy ; Ulcer*/pathology ; Ulcer*/surgery ; Young Adult
Abstract
BACKGROUND: The aims of this study were to evaluate the efficacy of medical treatments and to identify factors to predict clinical outcome of intestinal Behçet disease (BD) during medical treatment. METHODS: We performed a retrospective review of the medical records of 93 patients who were diagnosed and medically treated with intestinal BD at Severance Hospital, Seoul, Korea from 1992 to 2007. A therapeutic response was evaluated 8 weeks after the initiation of medical treatment, and cumulative recurrence and surgery rates were also assessed during long-term follow-up. RESULTS: The initial remission rate at 8 weeks after treatment was 66.7%. During the follow-up period, cumulative recurrence rates for intestinal BD were 24.9% at 2 years and 43.0% at 5 years. The recurrence rate was significantly higher in patients with apparent gastrointestinal symptoms at their initial presentation, volcano-type and deep intestinal ulcers, and those who failed to achieve complete remission during the initial treatment. Cumulative rates for surgery were 6.7% at 2 years and 15.1% at 5 years. The typical type of ulcers was the only predictive factor for the likelihood of surgery. CONCLUSIONS: Our study demonstrates that a considerable number of patients experience disease relapse during follow-up despite a high-remission rate after medical treatment for intestinal BD. Careful observation and intensive treatment should be carried out, especially in patients without complete remission after initial treatment, with deep and volcano-shaped ulcers, or with apparent gastrointestinal symptoms at the time of diagnosis
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004836-201007000-00002&LSLINK=80&D=ovft
DOI
10.1097/MCG.0b013e3181c8a50f
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Park, Jae Jun(박재준)
Chung, Moon Jae(정문재) ORCID logo https://orcid.org/0000-0002-5920-8549
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101228
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