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CDK4와 hTERT를 도입한 HPV16 E6/E7 불멸화 세포의 확립

Other Titles
 Establishment of CDK4/hTERT-Transfected HPV16 E6/E7 Immortalized Cell Lines 
Authors
 박영진  ;  홍두표  ;  김은철  ;  오봉경  ;  김진 
Citation
 Korean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지), Vol.34(1) : 27-36, 2010 
Journal Title
 Korean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지) 
ISSN
 1225-1577 
Issue Date
2010
Keywords
hcdk4 ; HPV16 E6/E7 ; hTERT ; Immortalization
Abstract
Human papillomavirus (HPV) has been classified as one of the causing factors of head and neck squamous cell carcinoma (HNSCC). However, little is known about HPV-related carcinogenesis in HNSCC. The purpose of this study is to characterize immortalized human oral keratinocyte (IHOK) transfected by HPV16 E6/E7, IHOK/hcdk4 (IHOK transfected by pLXRN-hcdk4) and IHOK/hcdk4/hTERT (IHOK transfected by pLPC-hTERT-hcdk4) to reconstitute HNSCC in vitro. Conclusively, we established a new immortalized cell lines, IHOK/hcdk4 and IHOK/hcdk4/hTERT, to understand multistep carcinogenic process of oncogenic HPV16 E6/E7 in HNSCC
Files in This Item:
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Cancer Metastasis Research Center (암전이연구센터) > 1. Journal Papers
Yonsei Authors
Kim, Jin(김진)
Park, Young Jin(박영진)
Oh, Bong Kyeong(오봉경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101204
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