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Phase II study of preoperative chemoradiotherapy (CRT) with irinotecan plus S-1 in locally advanced rectal cancer

DC FieldValueLanguage
dc.contributor.author정현철-
dc.contributor.author정희철-
dc.contributor.author천재희-
dc.contributor.author최혜진-
dc.contributor.author금기창-
dc.contributor.author김남규-
dc.contributor.author김호근-
dc.contributor.author노재경-
dc.contributor.author라선영-
dc.contributor.author백승혁-
dc.contributor.author신상준-
dc.contributor.author안중배-
dc.contributor.author임준석-
dc.date.accessioned2015-04-23T16:45:55Z-
dc.date.available2015-04-23T16:45:55Z-
dc.date.issued2010-
dc.identifier.issn0167-8140-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101182-
dc.description.abstractBACKGROUND AND PURPOSE: The aim of this study is to evaluate the efficacy and safety of preoperative radiation therapy combined with S-1 and irinotecan (SI) in LARC. MATERIALS AND METHODS: Patients were considered LARC if they had a T3/T4 lesion or node positive. Weekly doses of 40 mg/m(2) irinotecan were intravenously administered once per week during weeks 1-5 of radiotherapy. S-1 (70 mg/m(2)) was given from Monday to Friday in all weeks of radiotherapy. 3-D conformal radiotherapy was given at daily fractions of 1.8Gy for 5days for a total dose of 50.4 (45+5.4)Gy. Surgery was performed 4-6 weeks following the completion of chemoradiation. RESULTS: Between June 2006 and November 2007, 43 pts were enrolled. The stage was: cT3 24 patients, cT4 6 patients; 28 patients were cN+. Forty-one patients completed the chemoradiation and 42 patients underwent operation: a low anterior resection was performed in 36 patients, a total colectomy in 1 patient, and an abdominal perineal resection in 5 patients. T downstaging was observed in 50%; 23 N+ patients became N- (55%). The complete pathological response was observed in 9 patients (21%). The 3-year locoregional failure rate, distant failure rate, disease-free survival, and overall survival were 9.5%, 18.6%, 72.1%, and 94.3%, respectively. Only three patients experienced G3 diarrhea; one had G3 sepsis and two had septic shock. Hematological toxicity (G3-G4) was observed in five patients. CONCLUSIONS: This study demonstrated the efficacy of preoperative CRT with S-1 and irinotecan with 21% of complete response. However, prompt recognition and management of infection is needed to use it in patients with locally advanced rectal cancer-
dc.description.statementOfResponsibilityopen-
dc.format.extent303~307-
dc.relation.isPartOfRadiotherapy and Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePhase II study of preoperative chemoradiotherapy (CRT) with irinotecan plus S-1 in locally advanced rectal cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorSang Joon Shin-
dc.contributor.googleauthorNam Kyu Kim-
dc.contributor.googleauthorKi Chang Keum-
dc.contributor.googleauthorHo Geun Kim-
dc.contributor.googleauthorJun Seok Im-
dc.contributor.googleauthorHye Jin Choi-
dc.contributor.googleauthorSeung Hyuk Baik-
dc.contributor.googleauthorJae Hee Choen-
dc.contributor.googleauthorHei-Cheul Jeung-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorJae Kyung Roh-
dc.contributor.googleauthorHyun Cheol Chung-
dc.contributor.googleauthorJoong Bae Ahn-
dc.identifier.doi10.1016/j.radonc.2010.02.003-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03773-
dc.contributor.localIdA04219-
dc.contributor.localIdA00272-
dc.contributor.localIdA00353-
dc.contributor.localIdA01183-
dc.contributor.localIdA01290-
dc.contributor.localIdA01827-
dc.contributor.localIdA02105-
dc.contributor.localIdA02262-
dc.contributor.localIdA03408-
dc.contributor.localIdA03794-
dc.contributor.localIdA01316-
dc.contributor.localIdA04030-
dc.relation.journalcodeJ02597-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0167814010000800-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameJeung, Hei Cheul-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.alternativeNameChoi, Hye Jin-
dc.contributor.alternativeNameKeum, Ki Chang-
dc.contributor.alternativeNameKim, Nam Kyu-
dc.contributor.alternativeNameKim, Ho Keun-
dc.contributor.alternativeNameRoh, Jae Kyung-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameBaik, Seung Hyuk-
dc.contributor.alternativeNameShin, Sang Joon-
dc.contributor.alternativeNameAhn, Joong Bae-
dc.contributor.alternativeNameLim, Joon Seok-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorChoi, Hye Jin-
dc.contributor.affiliatedAuthorKeum, Ki Chang-
dc.contributor.affiliatedAuthorKim, Nam Kyu-
dc.contributor.affiliatedAuthorKim, Ho Keun-
dc.contributor.affiliatedAuthorRoh, Jae Kyung-
dc.contributor.affiliatedAuthorBaik, Seung Hyuk-
dc.contributor.affiliatedAuthorShin, Sang Joon-
dc.contributor.affiliatedAuthorAhn, Joong Bae-
dc.contributor.affiliatedAuthorLim, Joon Seok-
dc.contributor.affiliatedAuthorJeung, Hei Cheul-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.contributor.affiliatedAuthorCheon, Jae Hee-
dc.citation.volume95-
dc.citation.number3-
dc.citation.startPage303-
dc.citation.endPage307-
dc.identifier.bibliographicCitationRadiotherapy and Oncology, Vol.95(3) : 303-307, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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