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Anti-inflammatory effects of licorice and roasted licorice extracts on TPA-induced acute inflammation and collagen-induced arthritis in mice

 Ki RimKim  ;  Chan-Kwon Jeong  ;  Kwang-Kyun Park  ;  Jong-Hoon Choi  ;  Jung Han Yoon Park  ;  Soon Sung Lim  ;  Won-Yoon Chung 
 Journal of Biomedicine & Biotechnology, Vol.2010 : 709378, 2010 
Journal Title
Journal of Biomedicine & Biotechnology
Issue Date
Animals ; Arthritis/chemically induced ; Arthritis/drug therapy* ; Arthritis/pathology ; Collagen ; Disease Models, Animal* ; Female Glycyrrhiza/chemistry* ; Humans ; Inflammation/chemically induced ; Inflammation/drug therapy* ; Inflammation/pathology* ; Male ; Mice ; Mice, Inbred DBA ; Mice, Inbred ICR ; Plant Extracts/administration & dosage* ; Treatment Outcome
The anti-inflammatory activity of licorice (LE) and roasted licorice (rLE) extracts determined in the murine phorbol ester-induced acute inflammation model and collagen-induced arthritis (CIA) model of human rheumatoid arthritis. rLE possessed greater activity than LE in inhibiting phorbol ester-induced ear edema. Oral administration of LE or rLE reduced clinical arthritis score, paw swelling, and histopathological changes in a murine CIA. LE and rLE decreased the levels of proinflammatory cytokines in serum and matrix metalloproteinase-3 expression in the joints. Cell proliferation and cytokine secretion in response to type II collagen or lipopolysaccharide stimulation were suppressed in spleen cells from LE or rLE-treated CIA mice. Furthermore, LE and rLE treatment prevented oxidative damages in liver and kidney tissues of CIA mice. Taken together, LE and rLE have benefits in protecting against both acute inflammation and chronic inflammatory conditions including rheumatoid arthritis. rLE may inhibit the acute inflammation more potently than LE.
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2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Rim(김기림)
Park, Kwang Kyun(박광균)
Chung, Won Yoon(정원윤) ORCID logo https://orcid.org/0000-0001-8428-9005
Choi, Jong Hoon(최종훈) ORCID logo https://orcid.org/0000-0003-3211-3619
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