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Anaerobiosis of Pseudomonas aeruginosa: Implications for Treatments of Airway Infection

Authors
 Sang Sun Yoon 
Citation
 Journal of Bacteriology and Virology, Vol.40(2) : 59-66, 2010 
Journal Title
Journal of Bacteriology and Virology
ISSN
 1598-2467 
Issue Date
2010
Keywords
Pseudomonas aeruginosa ; Anaerobic environments ; Biofilm ; Quorum sensing
Abstract
Pseudomonas aeruginosa, as an opportunistic pathogen, establishes a chronic infection in the respiratory track of patients suffering from pneumonia and bronchiectasis, including cystic fibrosis. Biofilm formation inside the oversecreted mucus layer lining the patient airway and production of virulence factors, a process controlled by quorum sensing, are considered to be the major virulence determinants in P. aeruginosa pathogenesis. Recently, an abnormally thickened mucus layer was proven to be anaerobic. Given the fact that currently used antibiotics are less effective under anaerobic environments, these new findings lead us to change the way we confront P. aeruginosa infection. This article reviews pathological features of patient airways that become susceptible to P. aeruginosa infection and bacterial adaptation that contributes to the prolonged survival inside the patient airway.
Files in This Item:
T201001605.pdf Download
DOI
10.4167/jbv.2010.40.2.59
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Sang Sun(윤상선) ORCID logo https://orcid.org/0000-0003-2979-365X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101129
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