Cited 3 times in
Diffusion tensor imaging of heterotopia: changes of fractional anisotropy during radial migration of neurons
DC Field | Value | Language |
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dc.contributor.author | 김진아 | - |
dc.contributor.author | 이승구 | - |
dc.date.accessioned | 2015-04-23T16:44:06Z | - |
dc.date.available | 2015-04-23T16:44:06Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101126 | - |
dc.description.abstract | PURPOSE: Diffusion tensor imaging provides better understanding of pathophysiology of congenital anomalies, involving central nervous system. This study was aimed to specify the pathogenetic mechanism of heterotopia, proved by diffusion tensor imaging, and establish new findings of heterotopia on fractional anisotropy maps. MATERIALS AND METHODS: Diffusion-weighted imaging data from 11 patients (M : F = 7 : 4, aged from 1 to 22 years, mean = 12.3 years) who visited the epilepsy clinic and received a routine seizure protocol MRI exam were retrospectively analyzed. Fractional anisotropy (FA) maps were generated from diffusion tensor imaging of 11 patients with heterotopia. Regions of interests (ROI) were placed in cerebral cortex, heterotopic gray matter and deep gray matter, including putamen. ANOVA analysis was performed for comparison of different gray matter tissues. RESULTS: Heterotopic gray matter showed signal intensities similar to normal gray matter on T1 and T2 weighted MRI. The measured FA of heterotopic gray matter was higher than that of cortical gray matter (0.236 +/- 0.011 vs. 0.169 +/- 0.015, p < 0.01, one way ANOVA), and slightly lower than that of deep gray matter (0.236 +/- 0.011 vs. 0.259 +/- 0.016, p < 0.01). CONCLUSION: Increased FA of heterotopic gray matter suggests arrested neuron during radial migration and provides better understanding of neurodevelopment. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 590~593 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Anisotropy | - |
dc.subject.MESH | Cell Movement | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Diffusion Tensor Imaging/methods* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Malformations of Cortical Development, Group II/diagnosis | - |
dc.subject.MESH | Malformations of Cortical Development, Group II/etiology | - |
dc.subject.MESH | Malformations of Cortical Development, Group II/pathology* | - |
dc.title | Diffusion tensor imaging of heterotopia: changes of fractional anisotropy during radial migration of neurons | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Seung-Koo Lee | - |
dc.contributor.googleauthor | Jinna Kim | - |
dc.identifier.doi | 10.3349/ymj.2010.51.4.590 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01022 | - |
dc.contributor.localId | A02912 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 20499428 | - |
dc.subject.keyword | Heterotopia | - |
dc.subject.keyword | congenital malformation | - |
dc.subject.keyword | magnetic resonance imaging | - |
dc.contributor.alternativeName | Kim, Jinna | - |
dc.contributor.alternativeName | Lee, Seung Koo | - |
dc.contributor.affiliatedAuthor | Kim, Jinna | - |
dc.contributor.affiliatedAuthor | Lee, Seung Koo | - |
dc.citation.volume | 51 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 590 | - |
dc.citation.endPage | 593 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.51(4) : 590-593, 2010 | - |
dc.identifier.rimsid | 50847 | - |
dc.type.rims | ART | - |
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