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Changes in cerebral glucose metabolism in patients with posttraumatic cognitive impairment after memantine therapy: a preliminary study

 Yong Wook Kim  ;  Ji-Cheol Shin  ;  Young-sil An 
 ANNALS OF NUCLEAR MEDICINE, Vol.24(5) : 363-369, 2010 
Journal Title
Issue Date
Adult ; Aged ; Brain/drug effects* ; Brain/metabolism* ; Brain/physiopathology ; Brain Injuries/complications* ; Cognition Disorders/drug therapy* ; Cognition Disorders/etiology ; Cognition Disorders/metabolism* ; Cognition Disorders/physiopathology ; Female ; Glucose/metabolism* ; Humans ; Male ; Memantine/pharmacology ; Memantine/therapeutic use* ; Middle Aged ; Young Adult
Cerebral metabolism ; Posttraumatic cognitive impairment ; Memantine
OBJECTIVE: To investigate the changes in cerebral glucose metabolism in patients with posttraumatic cognitive impairment after memantine therapy. METHODS: We performed serial F-18 fluorodeoxyglucose positron emission tomography studies before and after memantine therapy (20 mg per day) on 17 patients with posttraumatic cognitive impairment using statistical parametric mapping analysis. In addition, covariance analysis was performed to identify regions, where changes in regional cerebral glucose metabolism correlated significantly with increased Mini-Mental Status Examination scores. RESULTS: Statistical parametric mapping analysis demonstrated that, compared with baseline, significantly increased cerebral glucose metabolism occurred in both inferior, middle and superior frontal gyri, both angular gyri, both precuneus, the right middle cingulum, the left inferior parietal lobule, the left fusiform gyrus, the left precentral gyrus, the left paracentral lobule, and the left lingual gyrus after memantine therapy (P (uncorrected) < 0.005). In contrast, cerebral glucose metabolism was significantly decreased in both cerebellum, the left thalamus, the left olfactory, the right middle temporal gyrus, the right amygdala, and the right insula (P (uncorrected) < 0.005). In the correlation analysis, improvements in Mini-Mental Status Examination scores after memantine therapy were significantly associated with increased cerebral glucose metabolism in the inferior and middle frontal gyri and the inferior parietal lobule of the left hemisphere (P (corrected) < 0.0001). CONCLUSIONS: Our findings indicate that the prefrontal and the parietal association cortices may be the relevant structures for the pharmacological response to memantine therapy in patients with posttraumatic cognitive impairment
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1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Wook(김용욱) ORCID logo https://orcid.org/0000-0002-5234-2454
Shin, Ji Cheol(신지철) ORCID logo https://orcid.org/0000-0002-1133-1361
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