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The prevalence and clinical significance of perinuclear anti-neutrophil cytoplasmic antibody in Korean patients with ulcerative colitis

 Jin Ha Lee  ;  Jae Hee Cheon  ;  Eun Soo Kim  ;  Moon Jae Chung  ;  Wonseok Kang  ;  Duk Hwan Kim  ;  You Jung Ha  ;  Jae Jun Park  ;  Tae Il Kim  ;  Won Ho Kim 
 DIGESTIVE DISEASES AND SCIENCES, Vol.55(5) : 1406-1412, 2010 
Journal Title
Issue Date
Adult ; Antibodies, Antineutrophil Cytoplasmic/immunology* ; Chi-Square Distribution ; Colitis, Ulcerative/immunology* ; Female ; Fluorescent Antibody Technique, Indirect ; Humans ; Korea ; Male ; Prevalence
Disease activity ; Korean ; pANCA ; Prevalence ; Ulcerative colitis
Perinuclear anti-neutrophil cytoplasmic antibody (pANCA) is a serological marker associated with various immune-mediated diseases whose clinical significance and possible diagnostic roles in ulcerative colitis (UC) are still unclear. We aimed to evaluate the prevalence of pANCA expression and its association with clinical findings and disease course in Korean patients with UC. This study included 484 patients with UC who were diagnosed and treated between 1990 and 2006 at Severance Hospital, Yonsei University, Seoul, Korea, and were followed for at least 1 year. Clinical findings at diagnosis, disease extent, treatment modalities used, and cumulative relapse rates were analyzed and compared to pANCA expression. Of the 484 patients, 405 (83.7%) were evaluated for pANCA and were eligible for analysis. The overall pANCA prevalence was 22.1%, with a female preponderance (male, 21.5%; female, 31.6%; P < 0.05). Proctitis was more common in pANCA-negative patients (pANCA-negative, 37.6%; pANCA-positive, 25.2%, P < 0.05). UC activity index and cumulative relapse rates were higher in pANCA-positive patients. However, there were no significant differences in the cumulative probability of steroid and immunosuppressant use and operation rate between the two groups. The prevalence of pANCA expression in Korean patients with UC was relatively low compared to that in Western countries. Although UC patients with pANCA expression had more severe clinical findings at diagnosis and higher cumulative relapse rates in our study, further prospective studies are warranted to clarify whether pANCA positivity influences the initial clinical presentation or disease aggressiveness
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6. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Won Suk(강원석)
Kim, Duk Hwan(김덕환)
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Eun Soo(김은수)
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Park, Jae Jun(박재준)
Lee, Jin Ha(이진하)
Chung, Moon Jae(정문재) ORCID logo https://orcid.org/0000-0002-5920-8549
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
Ha, You Jung(하유정)
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