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Interaction effects between COMT and BDNF polymorphisms on boredom susceptibility of sensation seeking traits.

Authors
 Jee In Kang  ;  Dong-Ho Song  ;  Kee Namkoong  ;  Se Joo Kim 
Citation
 PSYCHIATRY RESEARCH-NEUROIMAGING, Vol.178(1) : 132-136, 2010 
Journal Title
 PSYCHIATRY RESEARCH-NEUROIMAGING 
ISSN
 0925-4927 
Issue Date
2010
MeSH
Adult ; Arousal/genetics ; Boredom* ; Brain-Derived Neurotrophic Factor/genetics* ; Catechol O-Methyltransferase/genetics* ; Choice Behavior/physiology ; Exploratory Behavior/physiology ; Female ; Gene Frequency ; Genetic Predisposition to Disease* ; Genotype ; Humans ; Male ; Phenotype ; Polymorphism, Genetic/genetics* ; Risk-Taking ; Sensation/genetics* ; Sex Factors ; Young Adult
Keywords
Sensation seeking ; Boredom ; COMT ; BDNF ; Interaction ; Association study
Abstract
Sensation seeking is a temperament associated with willingness to take risks to obtain arousal. We investigated the relationship between the polymorphisms of the COMT Val158Met and BDNF Val66Met and sensation seeking traits. The Sensation Seeking Scale (SSS) and genotyping were performed in 277 Korean healthy volunteers (165 males, 112 females). Multivariate analysis of covariance was used to test the association between the COMT and BDNF functional polymorphisms and dimensions of sensation seeking, namely, disinhibition, boredom susceptibility, experience seeking and thrill/adventure seeking. No main and interaction effects of the COMT and BDNF on SSS were observed for total subjects. However, in females, a significant gene-gene interaction effect on the boredom susceptibility of SSS was shown. Among females with COMT Met present genotype (Val/Met+Met/Met), subjects with BDNF Met absent genotype (Val/Val) had significantly higher boredom susceptibility than subjects with BDNF Met. The effects of BDNF Val66Met polymorphism on boredom susceptibility of sensation seeking traits could be modulated by COMT Val158Met polymorphism in female
Full Text
http://www.sciencedirect.com/science/article/pii/S0165178110001605
DOI
10.1016/j.psychres.2010.04.001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
Song, Dong Ho(송동호) ORCID logo https://orcid.org/0000-0002-9647-3130
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101061
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