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세포검사로 유두갑상샘암종이 의심되는 갑상샘 결절의 Galectin-3 발현과 BRAF 돌연변이 분석
DC Field | Value | Language |
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dc.contributor.author | 곽진영 | - |
dc.contributor.author | 구자승 | - |
dc.contributor.author | 김현기 | - |
dc.contributor.author | 임범진 | - |
dc.contributor.author | 홍순원 | - |
dc.date.accessioned | 2015-04-23T16:41:59Z | - |
dc.date.available | 2015-04-23T16:41:59Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1738-1843 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101059 | - |
dc.description.abstract | BACKGROUND: Fine needle aspiration, which is known as the most accurate and cost-effective method for diagnosis of thyroid nodule, still may result in indeterminate cases that are pauci-cellular and show minor nuclear atypia, but most cases are associated with suspicion of papillary thyroid carcinoma (PTC). A B-type Raf kinase (BRAF) mutation was found in about half of PTCs and galectin-3 was expressed by malignant tumors, helping us to differentiate malignancies from benign lesions. METHODS: Cases studied included histologically 44 confirmed PTC cases and 18 benign cases previously diagnosed as suspicious of PTC using cytologic examination. Cases were analyzed for galectin-3 expression by immunohistochemical staining and BRAF mutation by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with a new restriction enzyme. RESULTS: All 44 cases of PTC and 8 of 18 benign controls expressed galectin-3. BRAF mutations were found in only 9 of the 44 PTC cases. Assessment of galectin-3 expression demonstrated high sensitivity but low specificity. Evaluation of BRAF mutation revealed high specificity and low sensitivity. CONCLUSIONS: This study suggests that the combined application of these two methods for PTC of suspicious cytology is complementary | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 191~198 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 세포검사로 유두갑상샘암종이 의심되는 갑상샘 결절의 Galectin-3 발현과 BRAF 돌연변이 분석 | - |
dc.title.alternative | Galectin-3 Expression and BRAF Mutation in Cases of Cytologically Suspicious Papillary Thyroid Carcinoma. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | 김도경 | - |
dc.contributor.googleauthor | 김현기 | - |
dc.contributor.googleauthor | 곽진영 | - |
dc.contributor.googleauthor | 김민주 | - |
dc.contributor.googleauthor | 정형재 | - |
dc.contributor.googleauthor | 구자승 | - |
dc.contributor.googleauthor | 임범진 | - |
dc.contributor.googleauthor | 정찬권 | - |
dc.contributor.googleauthor | 홍순원 | - |
dc.identifier.doi | 10.4132/KoreanJPathol.2010.44.2.191 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00182 | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A01108 | - |
dc.contributor.localId | A03363 | - |
dc.contributor.localId | A04411 | - |
dc.relation.journalcode | J02092 | - |
dc.identifier.eissn | 2092-8920 | - |
dc.subject.keyword | Suspicious cytology | - |
dc.subject.keyword | Biopsy, fine needle | - |
dc.subject.keyword | BRAF mutation | - |
dc.subject.keyword | Galectin-3 | - |
dc.contributor.alternativeName | Kwak, Jin Young | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Kim, Hyun Ki | - |
dc.contributor.alternativeName | Lim, Beom Jin | - |
dc.contributor.alternativeName | Hong, Soon Won | - |
dc.contributor.affiliatedAuthor | Kwak, Jin Young | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Ki | - |
dc.contributor.affiliatedAuthor | Lim, Beom Jin | - |
dc.contributor.affiliatedAuthor | Hong, Soon Won | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 44 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 191 | - |
dc.citation.endPage | 198 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PATHOLOGY , Vol.44(2) : 191-198, 2010 | - |
dc.identifier.rimsid | 50805 | - |
dc.type.rims | ART | - |
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