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Increased serum thymic stromal lymphopoietin in children with atopic dermatitis

Authors
 Eun Byoul Lee  ;  Kyung Won Kim  ;  Jung Yeon Hong  ;  Hye Mi Jee  ;  Myung Hyun Sohn  ;  Kyu-Earn Kim 
Citation
 PEDIATRIC ALLERGY AND IMMUNOLOGY, Vol.21(2 pt 2) : 457-460, 2010 
Journal Title
 PEDIATRIC ALLERGY AND IMMUNOLOGY 
ISSN
 0905-6157 
Issue Date
2010
MeSH
Adolescent ; Child ; Child, Preschool ; Cytokines/blood* ; Dermatitis, Atopic/metabolism ; Dermatitis, Atopic/physiopathology* ; Eczema/metabolism ; Eczema/physiopathology ; Eosinophils ; Female ; Humans ; Immunoglobulin E/blood ; Infant ; Leukocyte Count ; Male ; Severity of Illness Index
Keywords
atopic dermatitis ; atopy ; child ; thymic stromal lymphopoietin
Abstract
The present study investigated the relationship between serum thymic stromal lymphopoietin (TSLP) levels and the presence and severity of atopic dermatitis (AD). Serum TSLP levels, blood eosinophil counts, and serum total and specific immunoglobulin E (IgE) levels were measured in 232 children. Subjects were characterized as having atopic eczema (AE; n=75), non-atopic eczema (NAE; n=70), or normal controls (n=87). Serum TSLP levels in children with AD were significantly higher than normal controls but there were no differences in children with atopic and non-atopic eczema. However, serum TSLP levels in children with AD were not significantly correlated with disease severity, blood eosinophil counts and serum total IgE levels. Our findings show an association between TSLP and AD including both AE and NAE. It is suggested that TSLP may play a contributory role in the pathogenesis of AD regardless of the presence of atopy.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1399-3038.2009.00919.x/abstract
DOI
10.1111/j.1399-3038.2009.00919.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Lee, Eun Byoul(이은별)
Jee, Hye Mi(지혜미)
Hong, Jung Yeon(홍정연) ORCID logo https://orcid.org/0000-0003-0406-9956
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101042
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