1 471

Cited 37 times in

High dose-per-fraction irradiation of limited lung volumes using an image-guided, highly focused irradiator: simulating stereotactic body radiotherapy regimens in a small-animal model

Authors
 Jaeho Cho  ;  Reinhard Kodym  ;  Serguei Seliounine  ;  James A. Richardson  ;  Timothy D. Solberg  ;  Michael D. Story 
Citation
 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.77(3) : 895-902, 2010 
Journal Title
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
ISSN
 0360-3016 
Issue Date
2010
MeSH
Animals ; Bronchi/pathology ; Bronchi/radiation effects ; Constriction, Pathologic/pathology ; Dose Fractionation ; Equipment Design ; Humans ; Lung/pathology ; Lung/surgery* ; Mice ; Mice, Inbred C3H ; Pulmonary Alveoli/pathology ; Pulmonary Alveoli/radiation effects ; Pulmonary Atelectasis/pathology ; Pulmonary Fibrosis/etiology ; Pulmonary Fibrosis/pathology ; Radiation Injuries, Experimental/pathology* ; Radiosurgery/instrumentation ; Radiosurgery/methods*
Abstract
PURPOSE: To investigate the underlying biology associated with stereotactic body radiotherapy (SBRT), both in vivo models and image-guided, highly focal irradiation systems are necessary. Here, we describe such an irradiation system and use it to examine normal tissue toxicity in a small-animal model at lung volumes similar to those associated with human therapy.

METHODS AND MATERIALS: High-dose radiation was delivered to a small volume of the left lung of C3H/HeJCr mice using a small-animal stereotactic irradiator. The irradiator has a collimation mechanism to produce focal radiation beams, an imaging subsystem consisting of a fluorescent screen coupled to a charge-coupled device camera, and a manual positioning stage. Histopathologic examination and micro-CT were used to evaluate the radiation response.

RESULTS: Focal obliteration of the alveoli by fibrous connective tissue, hyperplasia of the bronchiolar epithelium, and presence of a small number of inflammatory cells are the main reactions to low-volume/high-dose irradiation of the mouse lung. The tissue response suggested a radiation dose threshold for early phase fibrosis lying between 40 and 100 Gy. The irradiation system satisfied our requirements of high-dose-rate, small beam diameter, and precise localization and verification.

CONCLUSIONS: We have established an experimental model and image-guided animal irradiation system for the study of high dose per fraction irradiations such as those used with SBRT at volumes analogous to those used in human beings. It will also allow the targeting of specific anatomical structures of the thorax or ultimately, orthotopic tumors of the lung.
Full Text
http://www.sciencedirect.com/science/article/pii/S0360301610000337
DOI
10.1016/j.ijrobp.2009.12.074
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Cho, Jae Ho(조재호) ORCID logo https://orcid.org/0000-0001-9966-5157
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101028
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links