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Effects of atorvastatin 20 mg, rosuvastatin 10 mg, and atorvastatin/ezetimibe 5 mg/5 mg on lipoproteins and glucose metabolism

Authors
 Ae-Young Her  ;  Jong-Youn Kim  ;  Seok-Min Kang  ;  Donghoon Choi  ;  Yangsoo Jang  ;  Namsik Chung  ;  Ichiro Manabe  ;  Sang-Hak Lee 
Citation
 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, Vol.15(2) : 167-174, 2010 
Journal Title
 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS 
ISSN
 1074-2484 
Issue Date
2010
MeSH
Adult ; Aged ; Anticholesteremic Agents/administration & dosage ; Anticholesteremic Agents/adverse effects ; Anticholesteremic Agents/therapeutic use* ; Apolipoprotein A-I/blood ; Apolipoproteins B/blood ; Atorvastatin Calcium ; Azetidines/administration & dosage ; Azetidines/adverse effects ; Azetidines/therapeutic use* ; Blood Glucose/analysis ; Body Mass Index ; Cholesterol/blood ; Cholesterol, LDL/blood* ; Drug Combinations ; Ezetimibe, Simvastatin Drug Combination ; Female ; Fluorobenzenes/administration & dosage ; Fluorobenzenes/adverse effects ; Fluorobenzenes/therapeutic use* ; Glucose/metabolism* ; Glycated Hemoglobin A/analysis ; Heptanoic Acids/administration & dosage ; Heptanoic Acids/adverse effects ; Heptanoic Acids/therapeutic use* ; Humans ; Male ; Middle Aged ; Pyrimidines/administration & dosage ; Pyrimidines/adverse effects ; Pyrimidines/therapeutic use* ; Pyrroles/administration & dosage ; Pyrroles/adverse effects ; Pyrroles/therapeutic use* ; Rosuvastatin Calcium ; Simvastatin/administration & dosage ; Simvastatin/adverse effects ; Simvastatin/therapeutic use* ; Sulfonamides/administration & dosage ; Sulfonamides/adverse effects ; Sulfonamides/therapeutic use*
Keywords
atorvastatin ; rosuvastatin ; ezetimibe ; apolipoproteins ; glucose
Abstract
The aim of this study was to compare the effects of 3 different statin regimens that have equivalent low-density lipoprotein cholesterol (LDL-C) lowering efficacy on the apolipoprotein B/A1 ratio and glucose metabolism. After a 4-week dietary lead-in, 90 hypercholeserolemic patients were randomly assigned to 1 of 3 treatment groups for 8 weeks: atorvastatin 20 mg, rosuvastatin 10 mg, or atorvastatin/ezetimibe 5 mg/5 mg. At drug treatment week 8, we compared the percentage changes in lipid parameters, apolipoprotein B/A1 ratio, hemoglobin A1c, and homeostasis model assessment-insulin resistance (HOMA-IR) from baseline. Seventy-six patients completed the study and the percentage changes in LDL-C were comparable among the groups. However, the percentage reduction in the apolipoprotein B/A1 ratio was significantly greater in the rosuvastatin group (-47% +/- 14%, P = .04) and the combination group (-46% +/- 8%, P = .05) than in the atorvastatin group (-39% +/- 11%). The percentage increase in hemoglobin A1c was small but significantly greater in the atorvastatin group compared to the combination group (3.0% +/- 5.2% and -0.4% +/- 4.0%, P = .03). The effect of rosuvastatin on hemoglobin A1c was not different from those of the other 2 regimens. The effects of 3 statin regimens were similar on HOMA-IR. In conclusion, 3 statin regimens have differential effect on apolipoprotein B/A1 and glycemic control after comparable LDL-C reduction.
Full Text
http://cpt.sagepub.com/content/15/2/167
DOI
10.1177/1074248409357922
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Kim, Jong Youn(김종윤) ORCID logo https://orcid.org/0000-0001-7040-8771
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Her, Ae Young(허애영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101009
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