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뇌하수체 선종환자의 수술 전 호르몬 변화와 propofol, remifentanil 마취제 요구량의 상관관계

Other Titles
 Correlations of preoperative hormonal changes with propofol and remifentanil requirements in pituitary adenoma patients 
 김은미  ;  최은미  ;  최승호  ;  허상백  ;  민경태 
 Anesthesia and Pain Medicine, Vol.5(2) : 146-150, 2010 
Journal Title
 Anesthesia and Pain Medicine 
Issue Date
Acupuncture ; Bullous pemphigoid ; Localized bullous pemphigoid
Background:Anesthetic requirements are affected by the preoperative levels of some hormones.This study investigated to identify the hormonal status such as plasma level and maximal secretary capacity correlating with propofol and remifentanil requirements in pituitary adenoma patients who show various hormonal secretory states perioperatively. Methods:From 51 adult female pituitary adenoma patients, preoperative basal values and maximal stimulated levels of various hormones related to the axis of hypothalamus-pituitary-target organs on combined pituitary function test were recorded.Total intravenous anesthesia using target controlled infusion with propofol and remifentanil was administered.The effect-site concentration (Ce) of propofol reaching anesthetic induction and the consumed dosages of propofol and remifentanil during operation were measured.Anesthetic maintenance was controlled within 30% of preanesthetic hemodynamic variables by remifentanil and within ranges of BIS 45 ± 10 by propofol. Spearman correlations between hormonal status and anesthetic requirements such as propofol Ce for induction, total consumed doses of propofol and remifentanil were performed with a statistical significance at P of 0.05. Results:The preoperative basal level of ACTH was correlated positively with propofol induction Ce and maintenance dose, and the maximal secretory capacity of prolactin also correlated positively with propofol induction Ce.Remifentanil consumption dose was not related with any hormones measured regardless of either preoperative basal levels or maximal secretory levels. Conclusions:Propofol requirements may be related with preoperative plasma level of ACTH or maximal secretory capacity of prolactin
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eun Mi(김은미)
Min, Kyeong Tae(민경태) ORCID logo https://orcid.org/0000-0002-3299-4500
Choi, Seung Ho(최승호) ORCID logo https://orcid.org/0000-0001-8442-4406
Choi, Eun Kyeong(최은경)
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