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How respiratory muscle strength correlates with cough capacity in patients with respiratory muscle weakness

Authors
 Jung Hyun Park  ;  Seong-Woong Kang  ;  Sang Chul Lee  ;  Won Ah Choi  ;  Dong Hyun Kim 
Citation
 Yonsei Medical Journal, Vol.51(3) : 392-397, 2010 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2010
MeSH
Adult ; Amyotrophic Lateral Sclerosis/physiopathology* ; Cough/physiopathology* ; Female ; Humans ; Inspiratory Capacity ; Male ; Middle Aged ; Muscle Strength/physiology* ; Muscle Weakness/pathology ; Muscle Weakness/physiopathology* ; Muscular Dystrophy, Duchenne/physiopathology* ; Respiratory Muscles/pathology ; Respiratory Muscles/physiopathology* ; Spinal Cord Injuries/physiopathology*
Keywords
Amyotrophic lateral sclerosis ; muscular dystrophy ; duchenne ; respiratory function tests, spinal cord injuries
Abstract
PURPOSE: The purpose of this study is to investigate how respiratory muscle strength correlates to cough capacity in patients with respiratory muscle weakness. MATERIALS AND METHODS: Forty-five patients with amyotrophic lateral sclerosis (ALS), 43 with cervical spinal cord injury (SCI), and 42 with Duchenne muscular dystrophy (DMD) were recruited. Pulmonary function tests including forced vital capacity (FVC) and respiratory muscle strength (maximal expiratory pressure, MEP; maximal inspiratory pressure, MIP) were performed. The correlation between respiratory muscle strength and cough capacity was analyzed. RESULTS: In the SCI group, FVC in a supine position (2,597 +/- 648 mL) was significantly higher than FVC in a sitting position (2,304 +/- 564 mL, p < 0.01). Conversely, in the ALS group, FVC sitting (1,370 +/- 604 mL) was significantly higher than in supine (1,168 +/- 599 mL, p < 0.01). In the DMD group, there was no statistically significant difference between FVC while sitting (1,342 +/- 506 mL) and FVC while supine (1,304 +/- 500 mL). In addition, the MEP and MIP of all three groups showed a significant correlation with peak cough flow (PCF) (p < 0.01, Pearson's correlation analysis). In the SCI group, MIP was more closely correlated with PCF, while in the ALS and DMD groups, MEP was more closely correlated with PCF (p < 0.01, multiple regression analysis). CONCLUSION: To generate cough flow, inspiratory muscle strength is significantly more important for SCI patients, while expiratory muscle function is significantly more important for ALS and DMD patients.
Files in This Item:
T201001088.pdf Download
DOI
10.3349/ymj.2010.51.3.392
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seong Woong(강성웅) ORCID logo https://orcid.org/0000-0002-7279-3893
Kim, Dong Hyun(김동현)
Choi, Won Ah(최원아) ORCID logo https://orcid.org/0000-0003-0403-8869
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100964
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