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Association between C-reactive protein and pulmonary function in postmenopausal women

Authors
 Dong-Hyuk Jung  ;  Yong-Jae Lee  ;  Hong-Yup Ahn  ;  Jae-Yong Shim  ;  Jung-Hyun Lee  ;  Hye-Ree Lee 
Citation
 MATURITAS, Vol.66(1) : 83-87, 2010 
Journal Title
 MATURITAS 
ISSN
 0378-5122 
Issue Date
2010
MeSH
C-Reactive Protein/metabolism* ; Female ; Forced Expiratory Volume* ; Humans ; Lung/physiology* ; Lung Diseases/physiopathology* ; Middle Aged ; Odds Ratio ; Postmenopause/physiology ; Risk Factors ; Vital Capacity*
Keywords
Inflammation ; C-reactive protein ; Pulmonary function ; Menopause
Abstract
OBJECTIVES: The objective of this study is to investigate the association of CRP and impaired pulmonary function in postmenopausal women. METHODS: The study was carried out in Gangnam Severance Hospital in Korea between March 2006 and October 2008. A total of 5978 healthy women subjects (age range, 20-75 years) were recruited from Seoul. We performed a cross-sectional study to evaluate the association of CRP with impaired pulmonary function, especially the restrictive pattern in 1555 nonsmoking postmenopausal women. We evaluated CRP as a categorical variable and constructed three groups (a very low risk group, CRP<0.5 mg/dl; a low risk group, 0.5-1.0 mg/dl; a medium and high risk group, 1.0-10.0 mg/dl). The odds ratios (ORs) for a low FVC were calculated across all three groups. RESULTS: CRP levels are negatively associated with forced expiratory volume (FEV(1))/forced vital capacity (FVC) and FVC after adjustment for confounding variables. The adjusted ORs (95% CIs) for a low FVC according to three groups were 1.00 (reference), 2.08 (1.03-4.20), and 2.55 (1.31-4.98) in postmenopausal women after adjusting for confounding variables. CONCLUSIONS: In summary, increased C-reactive protein (CRP) levels are strongly and independently associated with impaired pulmonary function and more frequent a low FVC in postmenopausal women.
Full Text
http://www.sciencedirect.com/science/article/pii/S0378512210001052
DOI
10.1016/j.maturitas.2010.02.015
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Hye Ree(이혜리)
Jung, Dong Hyuk(정동혁) ORCID logo https://orcid.org/0000-0002-3411-0676
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100955
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