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An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer

Authors
 Xianglan Zhang  ;  Jung-Jin Yang  ;  Yoon Sun Kim  ;  Ki-Yeol Kim  ;  Woong Shick Ahn  ;  Sanghwa Yang 
Citation
 International Journal of Oncology, Vol.36(2) : 405-414, 2010 
Journal Title
 International Journal of Oncology 
ISSN
 1019-6439 
Issue Date
2010
Abstract
We have identified an 8-gene signature with significant expression differences between gastric cancer and normal gastric tissues. This 8-gene set can predict the normal and cancer status of gastric tissues with more than 96% accuracy in a totally independent microarray dataset. The 8 genes are composed of down-regulated KLF4, GPX3, SST and LIPF, together with up-regulated SERPINH1, THY1 and INHBA in gastric cancer. To corroborate the differential gene expression pattern, we chose GPX3 and examined its expression pattern in detail. A comparison of GPX3 expression pattern shows a broader down-regulated pattern in multiple types of cancers, including cervical, thyroid, head and neck, lung cancers and melanoma than in healthy controls. An immuno-histostaining analysis in tissue microarrays confirms GPX3 down-regulation in gastric cancer. Mechanism-wise GPX3 down-regulation in gastric cancer is due to promoter hypermethylation. Collectively, these results show a correct identification of 8 genes as gastric cancer biomarkers.
Full Text
http://www.spandidos-publications.com/ijo/36/2/405
DOI
10.3892/ijo_00000513
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소)
Yonsei Authors
김기열(Kim, Ki Yeol) ORCID logo https://orcid.org/0000-0001-5357-1067
장향란(Zhang, Xiang Lan)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100859
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