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An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김기열 | - |
dc.contributor.author | 장향란 | - |
dc.date.accessioned | 2015-04-23T16:35:24Z | - |
dc.date.available | 2015-04-23T16:35:24Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100859 | - |
dc.description.abstract | We have identified an 8-gene signature with significant expression differences between gastric cancer and normal gastric tissues. This 8-gene set can predict the normal and cancer status of gastric tissues with more than 96% accuracy in a totally independent microarray dataset. The 8 genes are composed of down-regulated KLF4, GPX3, SST and LIPF, together with up-regulated SERPINH1, THY1 and INHBA in gastric cancer. To corroborate the differential gene expression pattern, we chose GPX3 and examined its expression pattern in detail. A comparison of GPX3 expression pattern shows a broader down-regulated pattern in multiple types of cancers, including cervical, thyroid, head and neck, lung cancers and melanoma than in healthy controls. An immuno-histostaining analysis in tissue microarrays confirms GPX3 down-regulation in gastric cancer. Mechanism-wise GPX3 down-regulation in gastric cancer is due to promoter hypermethylation. Collectively, these results show a correct identification of 8 genes as gastric cancer biomarkers. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 405~414 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/genetics* | - |
dc.subject.MESH | Adenocarcinoma/metabolism | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers, Tumor/genetics* | - |
dc.subject.MESH | Chromogranin A/biosynthesis | - |
dc.subject.MESH | Chromogranin A/genetics | - |
dc.subject.MESH | DNA Methylation/genetics* | - |
dc.subject.MESH | Down-Regulation | - |
dc.subject.MESH | Gene Expression Profiling | - |
dc.subject.MESH | Glutathione Peroxidase/biosynthesis | - |
dc.subject.MESH | Glutathione Peroxidase/genetics* | - |
dc.subject.MESH | HSP47 Heat-Shock Proteins/biosynthesis | - |
dc.subject.MESH | HSP47 Heat-Shock Proteins/genetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Inhibin-beta Subunits/biosynthesis | - |
dc.subject.MESH | Inhibin-beta Subunits/genetics | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Kruppel-Like Transcription Factors/biosynthesis | - |
dc.subject.MESH | Kruppel-Like Transcription Factors/genetics | - |
dc.subject.MESH | Lipase/biosynthesis | - |
dc.subject.MESH | Lipase/genetics | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis | - |
dc.subject.MESH | Promoter Regions, Genetic | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Somatostatin/biosynthesis | - |
dc.subject.MESH | Somatostatin/genetics | - |
dc.subject.MESH | Stomach Neoplasms/genetics* | - |
dc.subject.MESH | Stomach Neoplasms/metabolism | - |
dc.subject.MESH | Thy-1 Antigens/biosynthesis | - |
dc.subject.MESH | Thy-1 Antigens/genetics | - |
dc.subject.MESH | Tissue Array Analysis | - |
dc.subject.MESH | Up-Regulation | - |
dc.title | An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Oral Cancer Research Institute (구강종양연구소) | - |
dc.contributor.googleauthor | Xianglan Zhang | - |
dc.contributor.googleauthor | Jung-Jin Yang | - |
dc.contributor.googleauthor | Yoon Sun Kim | - |
dc.contributor.googleauthor | Ki-Yeol Kim | - |
dc.contributor.googleauthor | Woong Shick Ahn | - |
dc.contributor.googleauthor | Sanghwa Yang | - |
dc.identifier.doi | 10.3892/ijo_00000513 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00337 | - |
dc.contributor.localId | A03489 | - |
dc.relation.journalcode | J01141 | - |
dc.identifier.eissn | 1791-2423 | - |
dc.identifier.pmid | 20043075 | - |
dc.identifier.url | http://www.spandidos-publications.com/ijo/36/2/405 | - |
dc.subject.keyword | gastric cancer | - |
dc.subject.keyword | biomarker | - |
dc.subject.keyword | gene expression profiling | - |
dc.subject.keyword | methylation | - |
dc.contributor.alternativeName | Kim, Ki Yeol | - |
dc.contributor.alternativeName | Zhang, Xiang Lan | - |
dc.contributor.affiliatedAuthor | Kim, Ki Yeol | - |
dc.contributor.affiliatedAuthor | Zhang, Xiang Lan | - |
dc.citation.volume | 36 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 405 | - |
dc.citation.endPage | 414 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF ONCOLOGY, Vol.36(2) : 405-414, 2010 | - |
dc.identifier.rimsid | 55265 | - |
dc.type.rims | ART | - |
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