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An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer

DC Field Value Language
dc.contributor.author김기열-
dc.contributor.author장향란-
dc.date.accessioned2015-04-23T16:35:24Z-
dc.date.available2015-04-23T16:35:24Z-
dc.date.issued2010-
dc.identifier.issn1019-6439-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100859-
dc.description.abstractWe have identified an 8-gene signature with significant expression differences between gastric cancer and normal gastric tissues. This 8-gene set can predict the normal and cancer status of gastric tissues with more than 96% accuracy in a totally independent microarray dataset. The 8 genes are composed of down-regulated KLF4, GPX3, SST and LIPF, together with up-regulated SERPINH1, THY1 and INHBA in gastric cancer. To corroborate the differential gene expression pattern, we chose GPX3 and examined its expression pattern in detail. A comparison of GPX3 expression pattern shows a broader down-regulated pattern in multiple types of cancers, including cervical, thyroid, head and neck, lung cancers and melanoma than in healthy controls. An immuno-histostaining analysis in tissue microarrays confirms GPX3 down-regulation in gastric cancer. Mechanism-wise GPX3 down-regulation in gastric cancer is due to promoter hypermethylation. Collectively, these results show a correct identification of 8 genes as gastric cancer biomarkers.-
dc.description.statementOfResponsibilityopen-
dc.format.extent405~414-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/genetics*-
dc.subject.MESHAdenocarcinoma/metabolism-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers, Tumor/genetics*-
dc.subject.MESHChromogranin A/biosynthesis-
dc.subject.MESHChromogranin A/genetics-
dc.subject.MESHDNA Methylation/genetics*-
dc.subject.MESHDown-Regulation-
dc.subject.MESHGene Expression Profiling-
dc.subject.MESHGlutathione Peroxidase/biosynthesis-
dc.subject.MESHGlutathione Peroxidase/genetics*-
dc.subject.MESHHSP47 Heat-Shock Proteins/biosynthesis-
dc.subject.MESHHSP47 Heat-Shock Proteins/genetics-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHInhibin-beta Subunits/biosynthesis-
dc.subject.MESHInhibin-beta Subunits/genetics-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHKruppel-Like Transcription Factors/biosynthesis-
dc.subject.MESHKruppel-Like Transcription Factors/genetics-
dc.subject.MESHLipase/biosynthesis-
dc.subject.MESHLipase/genetics-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHOligonucleotide Array Sequence Analysis-
dc.subject.MESHPromoter Regions, Genetic-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHSomatostatin/biosynthesis-
dc.subject.MESHSomatostatin/genetics-
dc.subject.MESHStomach Neoplasms/genetics*-
dc.subject.MESHStomach Neoplasms/metabolism-
dc.subject.MESHThy-1 Antigens/biosynthesis-
dc.subject.MESHThy-1 Antigens/genetics-
dc.subject.MESHTissue Array Analysis-
dc.subject.MESHUp-Regulation-
dc.titleAn 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentOral Cancer Research Institute (구강종양연구소)-
dc.contributor.googleauthorXianglan Zhang-
dc.contributor.googleauthorJung-Jin Yang-
dc.contributor.googleauthorYoon Sun Kim-
dc.contributor.googleauthorKi-Yeol Kim-
dc.contributor.googleauthorWoong Shick Ahn-
dc.contributor.googleauthorSanghwa Yang-
dc.identifier.doi10.3892/ijo_00000513-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00337-
dc.contributor.localIdA03489-
dc.relation.journalcodeJ01141-
dc.identifier.eissn1791-2423-
dc.identifier.pmid20043075-
dc.identifier.urlhttp://www.spandidos-publications.com/ijo/36/2/405-
dc.subject.keywordgastric cancer-
dc.subject.keywordbiomarker-
dc.subject.keywordgene expression profiling-
dc.subject.keywordmethylation-
dc.contributor.alternativeNameKim, Ki Yeol-
dc.contributor.alternativeNameZhang, Xiang Lan-
dc.contributor.affiliatedAuthorKim, Ki Yeol-
dc.contributor.affiliatedAuthorZhang, Xiang Lan-
dc.citation.volume36-
dc.citation.number2-
dc.citation.startPage405-
dc.citation.endPage414-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF ONCOLOGY, Vol.36(2) : 405-414, 2010-
dc.identifier.rimsid55265-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers

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