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Expression of cyclooxygenase-2 in eutopic endometrium and ovarian endometriotic tissue in women with severe endometriosis.

Authors
 Cho S.  ;  Park S.H.  ;  Choi Y.S.  ;  Seo S.K.  ;  Kim H.Y.  ;  Park K.H.  ;  Cho D.J.  ;  Lee B.S 
Citation
 GYNECOLOGIC AND OBSTETRIC INVESTIGATION, Vol.69(2) : 93-100, 2010 
Journal Title
 GYNECOLOGIC AND OBSTETRIC INVESTIGATION 
ISSN
 0378-7346 
Issue Date
2010
MeSH
Adult ; CA-125 Antigen/blood ; Cyclooxygenase 2/biosynthesis* ; Cyclooxygenase 2/genetics ; Endometriosis/blood ; Endometriosis/enzymology* ; Endometriosis/genetics ; Female ; Gene Expression Regulation, Enzymologic ; Humans ; Ovarian Diseases/blood ; Ovarian Diseases/enzymology* ; Ovarian Diseases/genetics ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Statistics, Nonparametric
Keywords
Endometriosis ; Cyclooxygenase-2 ; Reverse transcriptase ; polymerase chain reaction
Abstract
BACKGROUND/AIMS: The purpose of this study is to evaluate the level and pattern of cyclooxygenase-2 (Cox-2) expression in endometriosis and to investigate the correlation between the expression of Cox-2 and several clinicosurgical parameters. METHODS: Twenty-six patients with endometriosis and 21 patients with other benign gynecological conditions were enrolled. The eutopic endometrium was sampled by pipelle, and fragments of ovarian endometrioma and non-endometriotic ovarian cysts were sampled during surgery. Total RNA isolation and semiquantitative reverse transcriptase polymerase chain reaction was performed. RESULTS: The expression of Cox-2 mRNA (mean +/- SEM) in eutopic endometrium and ovarian endometriotic tissue significantly increased in patients with endometriosis compared with the controls. The expression of Cox-2 increased significantly in the proliferative phase in eutopic endometrium and in the secretory phase in ovarian endometriotic tissue of patients with endometriosis compared with the controls. Cox-2 mRNA expression in the endometrium and ovarian lesions significantly correlated with serum CA-125 and the diameter of the endometrioma. CONCLUSIONS: Cox-2 expression increased in the eutopic endometrium and ovarian endometriotic tissue of the patients with endometriosis. These findings indicate that Cox-2 may be involved in the pathogenesis and progression of endometriosis.
Full Text
http://www.karger.com/Article/FullText/261017
DOI
10.1159/000261017
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hye Yeon(김혜연)
Park, Ki Hyun(박기현)
Seo, Seok Kyo(서석교) ORCID logo https://orcid.org/0000-0003-3404-0484
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Cho, Dong Je(조동제)
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100532
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