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Intracoronary thrombus formation after drug-eluting stents implantation: optical coherence tomographic study

Authors
 Jung-Sun Kim  ;  Myeong-Ki Hong  ;  Chunyu Fan  ;  Tae-Hoon Kim  ;  Jae-Min Shim  ;  Sang-Min Park  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Yangsoo Jang 
Citation
 AMERICAN HEART JOURNAL, Vol.159(2) : 278-283, 2010 
Journal Title
 AMERICAN HEART JOURNAL 
ISSN
 0002-8703 
Issue Date
2010
MeSH
Coronary Thrombosis/diagnosis* ; Coronary Thrombosis/epidemiology ; Coronary Thrombosis/etiology* ; Drug-Eluting Stents/adverse effects* ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Middle Aged ; Time Factors ; Tomography, Optical Coherence*
Abstract
BACKGROUND: Intracoronary thrombus formation after drug-eluting stent (DES) implantation is not sufficiently evaluated. METHODS: Optical coherence tomography (OCT) was performed in 226 patients (total DES n = 244, sirolimus-eluting stent [SES] n = 95, paclitaxel-eluting stent [PES] n = 62, zotarolimus-eluting stent [ZES] n = 87) after implantation (mean 11 months, range 3-66 months). Using OCT, we investigated the incidence and determinants of intracoronary thrombus. RESULTS: Intracoronary thrombus was detected in 35 (14%) cases (27 SES [28%], 7 PES [11%], and 1 ZES [1%], P < .001) and was associated with longer stent, smaller stent diameter, and stents at bifurcation lesions. More uncovered stent struts (26 +/- 23 vs 8 +/- 17, P < .001) and malapposed stent struts (6 +/- 14 vs 2 +/- 6, P < .001) were also associated with intracoronary thrombus. Multiple logistic regression analysis found the following determinants of intracoronary thrombus: stent length > or =28 mm (odds ratio [OR] 7.31, 95% CI 1.79-29.86, P = .01), stent diameter <3.0 mm (OR 4.38, 95% CI 1.38-13.97, P = .01), and > or =8 uncovered struts in each stent (OR 3.29, 95% CI 1.07-10.17, P = .04). CONCLUSIONS: Length, size, and types of DES may be more important than clinical factors in intracoronary thrombus formation after DES implantations.
Full Text
http://www.sciencedirect.com/science/article/pii/S0002870309009545
DOI
10.1016/j.ahj.2009.11.029
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Kim, Tae Hoon(김태훈)
Park, Sang Min(박상민)
Shim, Jae Min(심재민)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100502
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