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Association between serum uric acid and non-alcoholic fatty liver disease in Korean adults

Authors
 Yong-Jae Lee  ;  Hye-Ree Lee  ;  Jung-Hyun Lee  ;  Youn-Ho Shin  ;  Jae-Yong Shim 
Citation
 CLINICAL CHEMISTRY AND LABORATORY MEDICINE, Vol.48(2) : 175-180, 2010 
Journal Title
 CLINICAL CHEMISTRY AND LABORATORY MEDICINE 
ISSN
 1434-6621 
Issue Date
2010
MeSH
Adult ; Age Factors ; Aged ; Blood Glucose/metabolism ; Blood Pressure ; Body Mass Index ; Cities ; Exercise ; Fatty Liver/blood* ; Fatty Liver/epidemiology* ; Fatty Liver/metabolism ; Fatty Liver/physiopathology ; Female ; Humans ; Insulin Resistance ; Lipids/blood ; Male ; Middle Aged ; Odds Ratio ; Republic of Korea/epidemiology ; Sex Factors ; Smoking ; Uric Acid/blood* ; Young Adult
Keywords
inflammation ; insulin resistance ; non-alcoholic fatty liver disease ; uric acid
Abstract
BACKGROUND: Increased uric acid is associated with the metabolic syndrome, conditions linked to oxidative stress and insulin resistance. Non-alcoholic fatty liver disease (NAFLD) is now considered a hepatic manifestation of insulin resistance. However, little has been written regarding the association between uric acid and NAFLD. METHODS: We examined the association between uric acid and the presence of NAFLD in 3768 Koreans (2133 men, 1635 women; aged 20-75 years) in a health examination program. Uric acid quartiles were categorized separately as follows: Q1: <or=291.5, Q2: 291.6-333.1, Q3: 333.2-380.7, and Q4: >or=380.8 micromol/L for men; Q1: <or=202.2, Q2: 202.3-232.0, Q3: 231.1-267.7, and Q4: >or=267.8 micromol/L for women. Hepatic steatosis was diagnosed based on abdominal ultrasonographic findings by hyperechogenicity of liver tissue, difference of echogenicity between the liver and diaphragm, and visibility of vascular structures. The odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were calculated across each quartile of serum uric acid. RESULTS: The prevalence of NAFLD was 25.8% (32.2% in men and 17.4% in women). After adjustment for age, body mass index (BMI), smoking, regular exercise, blood pressure, fasting plasma glucose (FPG), triglycerides, and high-density lipoprotein (HDL) cholesterol, the ORs (95% CIs) for NAFLD according to each quartile of uric acid were 1.00, 1.55 (1.13-2.14), 1.77 (1.30-2.41), and 2.01 (1.45-2.78) for men and 1.00, 0.69 (0.40-1.20), 1.12 (0.67-1.88), and 1.94 (1.21-3.13) for women. CONCLUSIONS: Serum uric acid is independently associated with the presence of NAFLD, and uric acid may be a useful additional measure in assessing the risk of NAFLD in the clinical setting.
Full Text
http://www.degruyter.com/view/j/cclm.2010.48.issue-2/cclm.2010.037/cclm.2010.037.xml
DOI
10.1515/CCLM.2010.037
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Youn Ho(신윤호)
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Hye Ree(이혜리)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100495
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