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Epidemiological link between gastric disease and polymorphisms in VacA and CagA

 Sungil Jang  ;  Kathleen R. Jones  ;  Cara H. Olsen  ;  Young Min Joo  ;  Yun-Jung Yoo  ;  In-Sik Chung  ;  Jeong-Heon Cha  ;  D. Scott Merrell 
 JOURNAL OF CLINICAL MICROBIOLOGY, Vol.48(2) : 559-567, 2010 
Journal Title
Issue Date
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Antigens, Bacterial/genetics* ; Bacterial Proteins/genetics* ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; Female ; Gastritis/epidemiology* ; Gastritis/microbiology ; Gene Frequency ; Genotype ; Helicobacter Infections/complications* ; Helicobacter Infections/microbiology ; Helicobacter pylori/genetics* ; Helicobacter pylori/isolation & purification ; Helicobacter pylori/pathogenicity ; Humans ; Korea ; Male ; Middle Aged ; Molecular Sequence Data ; Peptic Ulcer/epidemiology* ; Peptic Ulcer/microbiology ; Sequence Analysis, DNA ; Stomach Neoplasms/epidemiology* ; Stomach Neoplasms/microbiology ; Virulence Factors/genetics ; Young Adult
Gastritis, peptic ulcer disease, and gastric cancer are a few of the diverse disease manifestations that have been shown to be associated with infection by Helicobacter pylori. Why some individuals develop more severe forms of disease remains largely unknown. In this study, 225 South Korean strains were genotyped for vacA and then analyzed to determine if particular genotypes varied across disease state, sex, or cagA allele. Of these strains, 206 strains carried an s1/i1/m1 allele, 11 strains carried an s1/i1/m2 allele, and 8 strains carried an s1/i2/m2 allele. By using Fisher's exact test, a statistical association between variations in the cagA and vacA alleles was identified (P = 0.0007), and by using log linear modeling, this variation was shown to affect the severity of disease outcome (P = 0.027). Additionally, we present evidence that variation within the middle region of VacA contributes significantly to the distribution of vacA alleles across gender (P = 0.008) as well as the association with disease outcome (P = 0.011). In this South Korean population, the majority of H. pylori strains carry the vacA s1/i1/m1 allele and the CagA EPIYA-ABD allele. These facts may contribute to the high incidence of gastric maladies, including gastric cancer.
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2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Yoo, Yun Jung(유윤정) ORCID logo https://orcid.org/0000-0002-0045-9597
Jang, Sungil(장성일) ORCID logo https://orcid.org/0000-0001-6144-6899
Joo, Young Min(주영민)
Cha, Jung Heon(차정헌) ORCID logo https://orcid.org/0000-0002-9385-2653
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