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Innate immunity and gut-microbe mutualism in Drosophila

Authors
 Ji Hoon Jeong  ;  Sun Hwa Kim  ;  Lane V. Christensen  ;  Jan Feijen  ;  Sung Wan Kim 
Citation
 DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, Vol.34(4) : 369-376, 2010 
Journal Title
 DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 
ISSN
 0145-305X 
Issue Date
2010
MeSH
Animals ; Antimicrobial Cationic Peptides/immunology ; Drosophila/microbiology* ; Drosophila/physiology* ; Gastrointestinal Tract/microbiology* ; Gene Expression Regulation, Enzymologic ; Host-Pathogen Interactions ; Immunity, Innate* ; Reactive Oxygen Species/immunology ; Signal Transduction ; Symbiosis*
Keywords
Gut immunity ; Reactive oxygen species ; Dual oxidase ; Anti-microbial peptide ; NF-κB ; Drosophila
Abstract
Metazoan guts face a wide variety of microorganisms upon exposure to the environment, including beneficial symbionts, non-symbionts, food-borne microbes and life-threatening pathogens. Recent evidence has shown that the innate immunity of gut epithelia, such as anti-microbial peptide- and reactive oxygen species-based immune systems, actively participate in gut-microbe homeostasis by shaping the commensal community while efficiently eliminating unwanted bacteria. Therefore, elucidation of the regulatory mechanism by which gut innate immunity occurs at the molecular level will provide a novel perspective of gut-microbe mutualisms as well as of gut diseases caused by alterations in the innate immunity.
Full Text
http://www.sciencedirect.com/science/article/pii/S0145305X0900250X
DOI
10.1016/j.dci.2009.11.010
Appears in Collections:
5. Research Institutes (연구소) > Research Center for Human Natural Defense System (생체방어연구센터) > 1. Journal Papers
Yonsei Authors
Ryu, Ji Hwan(유지환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100485
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