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Cytochrome P450 1B1 polymorphisms and risk of renal cell carcinoma in men.

Authors
 Inik Chang  ;  Shinichiro Fukuhara  ;  Darryn K. Wong  ;  Ankurpreet Gill  ;  Yozo Mitsui  ;  Shahana Majid  ;  Sharanjot Saini  ;  Soichiro Yamamura  ;  Takeshi Chiyomaru  ;  Hiroshi Hirata  ;  Koji Ueno  ;  Sumit Arora  ;  Varahram Shahryari  ;  Guoren Deng  ;  Z. Laura Tabatabai  ;  Kirsten L. Greene  ;  Dong Min Shin  ;  Hideki Enokida  ;  Hiroaki Shiina  ;  Norio Nonomura  ;  Rajvir Dahiya  ;  Yuichiro Tanaka 
Citation
 Tumor Biology, Vol.35(10) : 10223-10230, 2014 
Journal Title
 Tumor Biology 
ISSN
 1010-4283 
Issue Date
2014
MeSH
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Renal Cell/enzymology ; Carcinoma, Renal Cell/genetics* ; Cytochrome P-450 CYP1B1/genetics* ; Genetic Predisposition to Disease/genetics* ; Genotype ; Humans ; Kidney Neoplasms/enzymology ; Kidney Neoplasms/genetics* ; Male ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide/genetics* ; Risk Factors
Keywords
Cytochrome P450 1B1 ; Polymorphisms ; Renal cell ; Cancer
Abstract
The cytochrome P450 1B1 (CYP1B1) enzyme activates xenobiotics to reactive forms as well as convert estradiol to 4-hydroxy-estradiol that has been shown to play a role in the carcinogenesis process of the kidney in male but not female animals. Prior reports show polymorphic variants of CYP1B1 to alter catalytic activity, and thus, we hypothesize that polymorphisms of the CYP1B1 gene are involved in the malignant transformation of the renal cell in men. The genetic distributions of five CYP1B1 polymorphisms were analyzed by polymerase chain reaction–restriction fragment length polymorphism in 480 normal healthy subjects and 403 sporadic renal cell carcinoma cases. All subjects were Caucasian men. The sites evaluated were codons 48 (C → G, Arg → Gly, rs10012), 119 (G → T, Ala → Ser, rs1056827), 432 (C → G, Leu → Val, rs1056836), 449 (C → T, Asp, rs1056837), and 453 (A → G, Asn → Ser, rs1800440). A trend was demonstrated for the 432 Val/Val (χ2, P = 0.06) and 449 T/T (χ2, P = 0.1) genotypes to play a protective role against renal cancer. Odds ratio (95 % confidence interval) for Val/Val compared to Leu/Leu at codon 432 was 0.65 (0.44–0.95) and T/T compared to C/C at codon 449 was 0.67 (0.45–0.99). Codons 432 and 449 were observed to be linked (D = 0.24), and haplotype involving 432 Val and 449 T was significantly reduced in cancer cases (P = 0.04). No association was found, however, when analyzing polymorphic sites with clinical stage of cancer. These results demonstrate polymorphisms of CYP1B1 to be associated with renal carcinogenesis and are of importance in understanding their role in the pathogenesis of renal cell carcinoma.
Full Text
http://link.springer.com/article/10.1007%2Fs13277-014-2292-3
DOI
10.1007/s13277-014-2292-3
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Shin, Dong Min(신동민) ORCID logo https://orcid.org/0000-0001-6042-0435
Chang, In Ik(장인익)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100324
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