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Urinary nerve growth factor correlates with the severity of urgency and pain

Authors
 Sang Woon Kim  ;  Young Jae Im  ;  Ho Chul Choi  ;  Hyo Jin Kang  ;  Ji Yu Kim  ;  Jang Hwan Kim 
Citation
 INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol.25(11) : 1561-1567, 2014 
Journal Title
 INTERNATIONAL UROGYNECOLOGY JOURNAL 
ISSN
 0937-3462 
Issue Date
2014
MeSH
Adult ; Aged ; Aged, 80 and over ; Cystitis, Interstitial/urine* ; Dinoprostone/urine* ; Female ; Humans ; Lower Urinary Tract Symptoms/urine ; Male ; Middle Aged ; Nerve Growth Factor/urine* ; Pain Measurement ; Severity of Illness Index ; Urinary Bladder, Overactive/urine* ; Young Adult
Keywords
Nerve growth factor ; Overactive bladder ; PGE2 ; Urge incontinence
Abstract
INTRODUCTION AND HYPOTHESIS: Urinary nerve-growth-factor (NGF) level reflected the severity of urgency in patients with lower urinary tract symptoms (LUTS) and pain in patients with Bladder pain syndrome/interstitial cystitis (BPS/IC). The aim of this study was to investigate the levels of biomarkers, nerve growth factor (NGF), and prostaglandin E2 (PGE2) among disease groups sharing similar urinary symptoms and to elucidate which symptoms are related to individual biomarker levels. METHODS: We studied 83 patients with LUTS who visited our outpatient clinic from May 2011 to December 2012. On the basis of clinical symptoms and a 3-day voiding diary, patients were classified into three groups: those with frequency (n = 13), overactive bladder (OAB) (n = 35), and BPS/IC (n = 35). Patients with stress urinary incontinence (SUI) or microscopic hematuria served as controls (n = 24). Storage symptoms were evaluated based on OAB symptom score (OAB-SS). RESULTS: Mean patient age was 62.08 ± 11.47 (range, 23-84). Urinary NGF and creatinine-normalized NGF levels were significantly increased in those with OAB (201.90 and 4.08, respectively) and BPS/IC (173.71 and 2.72) compared with controls (77.77 and 1.29) and those with frequency (67.76 and 1.23). Neither value significantly differed between OAB and BPS/IC patients or between controls and frequency patients. Urinary PGE2 and creatinine-normalized PGE2 levels were not significantly different among groups. On linear regression analysis, urinary NGF levels were significantly correlated with urgency severity overall (R = 0.222) and also pain in BPS/IC patients (R = 0.409). CONCLUSIONS: The levels of urinary NGF were elevated in patients with OAB and BPS/IC but not those with frequency and reflected the severity of urgency. In BPS/IC patients, urinary NGF increased with pain severity.
Full Text
http://link.springer.com/article/10.1007%2Fs00192-014-2424-8
DOI
10.1007/s00192-014-2424-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kang, Hyo Jin(강효진)
Kim, Sang Woon(김상운) ORCID logo https://orcid.org/0000-0002-5790-1948
Kim, Jang Hwan(김장환) ORCID logo https://orcid.org/0000-0002-9056-7072
Kim, Ji Yu(김지유)
Im, Young Jae(임영재)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100168
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