309 687

Cited 0 times in

Feasibility of robot-assisted radical prostatectomy for very-high risk prostate cancer: surgical and oncological outcomes in men aged ≥70 years.

DC Field Value Language
dc.contributor.author구교철-
dc.contributor.author나군호-
dc.contributor.author이승환-
dc.contributor.author정대철-
dc.contributor.author정병하-
dc.contributor.author최영득-
dc.contributor.author홍성준-
dc.date.accessioned2015-01-06T17:32:00Z-
dc.date.available2015-01-06T17:32:00Z-
dc.date.issued2014-
dc.identifier.issn2287-8882-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100156-
dc.description.abstractPURPOSE: Robot-assisted radical prostatectomy with pelvic lymph node dissection (RALP-PLND) is a feasible treatment option for high-risk prostate cancer (HPCa), but remains controversial for very high-risk prostate cancer (VHPCa). We aimed to assess the feasibility of RALP-PLND in men ≥70 years with VHPCa features by comparing outcomes to those of HPCa. METHODS: Among patients aged ≥70 years who underwent RALP-PLND between 2005 and 2012, 101 HPCa patients (31%) (PSA≥20 ng/mL or biopsy Gleason 8-10 or cT3a) and 53 VHPCa patients (16%) (≥cT3b or cN1) were identified. Perioperative, functional, and oncological outcomes were compared between groups. RESULTS: Perioperative outcomes including operative time (P=0.917), estimated blood loss (P=0.181), and complications (P=0.239) were comparable. Due to Gleason score downgrading, 19% of HPCa and 4% of VHPCa were actually of intermediate risk. VHPCa revealed higher LN involvements (P=0.002). Discrepancy between clinical and pathological nodal status was more frequent in VHPCa (36% vs. 7%, P<0.01). Nodal metastasis would have been missed in 23% patients without PLND, while 13% of cN1 patients were shown to be metastasis-free by PLND. Continence rates were lower for VHPCa (32% vs. 56%, P=0.013). Although biochemical recurrence-free survival rates were comparable (P=0.648), risk for later adjuvant treatments was higher for VHPCa patients (14% vs. 34%, P<0.01). CONCLUSIONS: RALP-PLND is a feasible option for VHPCa in elderly patients with satisfactory oncologic outcomes; however, functional outcomes were not as favorable. Patients who are unable to accept the risk of adjuvant therapy and its side effects or incontinence should be deterred from surgical treatment, and other options such as radiation therapy could be an alternative.-
dc.description.statementOfResponsibilityopen-
dc.format.extent127~132-
dc.relation.isPartOfPROSTATE INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleFeasibility of robot-assisted radical prostatectomy for very-high risk prostate cancer: surgical and oncological outcomes in men aged ≥70 years.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorKyo Chul Koo-
dc.contributor.googleauthorDae Chul Jung-
dc.contributor.googleauthorSeung Hwan Lee-
dc.contributor.googleauthorYoung Deuk Choi-
dc.contributor.googleauthorByung Ha Chung-
dc.contributor.googleauthorSung Joon Hong-
dc.contributor.googleauthorKoon Ho Rha-
dc.identifier.doi10.12954/PI.14050-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02938-
dc.contributor.localIdA00188-
dc.contributor.localIdA01227-
dc.contributor.localIdA03592-
dc.contributor.localIdA03607-
dc.contributor.localIdA04111-
dc.contributor.localIdA04402-
dc.relation.journalcodeJ02559-
dc.identifier.eissn2287-903X-
dc.identifier.pmid25325024-
dc.subject.keywordAged-
dc.subject.keywordProstate neoplasms-
dc.subject.keywordRobotics-
dc.subject.keywordTreatment outcome-
dc.contributor.alternativeNameKoo, Kyo Chul-
dc.contributor.alternativeNameRha, Koon Ho-
dc.contributor.alternativeNameLee, Seung Hwan-
dc.contributor.alternativeNameJung, Dae Chul-
dc.contributor.alternativeNameChung, Byung Ha-
dc.contributor.alternativeNameChoi, Young Deuk-
dc.contributor.alternativeNameHong, Sung Joon-
dc.contributor.affiliatedAuthorLee, Seung Hwan-
dc.contributor.affiliatedAuthorKoo, Kyo Chul-
dc.contributor.affiliatedAuthorRha, Koon Ho-
dc.contributor.affiliatedAuthorJung, Dae Chul-
dc.contributor.affiliatedAuthorChung, Byung Ha-
dc.contributor.affiliatedAuthorChoi, Young Deuk-
dc.contributor.affiliatedAuthorHong, Sung Joon-
dc.citation.volume2-
dc.citation.number3-
dc.citation.startPage127-
dc.citation.endPage132-
dc.identifier.bibliographicCitationPROSTATE INTERNATIONAL, Vol.2(3) : 127-132, 2014-
dc.identifier.rimsid51713-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.