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Early-stage chronic kidney disease, insulin resistance, and osteoporosis as risk factors of sarcopenia in aged population: The Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV), 2008–2009

Authors
 J. E. Kim  ;  Y.-h. Lee  ;  J. H. Huh  ;  D. R. Kang  ;  Y. Rhee  ;  S.-K. Lim 
Citation
 OSTEOPOROSIS INTERNATIONAL, Vol.25(9) : 2189-2198, 2014 
Journal Title
 OSTEOPOROSIS INTERNATIONAL 
ISSN
 0937-941X 
Issue Date
2014
MeSH
Absorptiometry, Photon/methods ; Aged ; Aged, 80 and over ; Bone Density/physiology ; Comorbidity ; Cross-Sectional Studies ; Female ; Femur Neck/physiopathology ; Health Behavior ; Humans ; Insulin Resistance/physiology* ; Male ; Nutrition Surveys ; Osteoporosis/complications* ; Osteoporosis/epidemiology ; Osteoporosis/physiopathology ; Renal Insufficiency, Chronic/complications* ; Renal Insufficiency, Chronic/epidemiology ; Republic of Korea/epidemiology ; Risk Factors ; Sarcopenia/epidemiology ; Sarcopenia/etiology* ; Sarcopenia/physiopathology ; Social Class
Keywords
Chronic kidney disease ; Insulin resistance ; Osteoporosis ; Sarcopenia
Abstract
Sarcopenia means the progressive loss of skeletal muscle mass and strength with aging. In this study, we found that insulin resistance, chronic kidney disease stage 3, and osteoporosis at the femur neck were closely associated with sarcopenia in elderly men. These conditions modified to slow down the progression of sarcopenia. INTRODUCTION: Sarcopenia is known to have multiple contributing factors; however, its modifiable risk factors have not yet been determined. The aim of this study was to identify the most influential and modifiable risk factors for sarcopenia in elderly. METHODS: This was a population-based, cross-sectional study using data from the Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV), 2008-2009. This study included 940 men and 1,324 women aged 65 years and older who completed a body composition analysis using dual-energy X-ray absorptiometry. Sarcopenia was defined as an appendicular skeletal muscle mass divided by height(2) of less than 1 standard deviation below the sex-specific mean for a younger reference group. RESULTS: Using univariate analysis, age, body mass index (BMI), homeostasis model assessment for insulin resistance (HOMA-IR), limitations in daily activities, regular exercise, high-risk drinking, family income, osteoporosis, daily energy, and protein intake were associated with sarcopenia in men; age, BMI, limitations in daily activities, regular exercise, occupation, osteoporosis at the total hip, and daily energy intake were associated with sarcopenia in women. In the multivariate logistic regression analysis, HOMA-IR ≥2.5 (odds ratio [OR] for sarcopenia, 2.27; 95 % confidence interval [CI], 1.21-4.25), chronic kidney disease stage 3 (OR, 3.13; 95 % CI, 1.14-8.61), and osteoporosis at the femur neck (OR, 6.83; 95 % CI, 1.08-43.41) were identified as risk factors for sarcopenia in men. CONCLUSIONS: Insulin resistance, chronic kidney disease, and osteoporosis at the femur neck should be modified to prevent the acceleration of skeletal muscle loss in elderly men.
Full Text
http://link.springer.com/article/10.1007%2Fs00198-014-2745-y
DOI
10.1007/s00198-014-2745-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jo Eun(김조은)
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lim, Sung Kil(임승길)
Huh, Ji Hye(허지혜)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100071
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