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Cited 36 times in

Early-stage chronic kidney disease, insulin resistance, and osteoporosis as risk factors of sarcopenia in aged population: The Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV), 2008–2009

DC Field Value Language
dc.contributor.author김조은-
dc.contributor.author이용호-
dc.contributor.author이유미-
dc.contributor.author임승길-
dc.contributor.author허지혜-
dc.date.accessioned2015-01-06T17:29:15Z-
dc.date.available2015-01-06T17:29:15Z-
dc.date.issued2014-
dc.identifier.issn0937-941X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100071-
dc.description.abstractSarcopenia means the progressive loss of skeletal muscle mass and strength with aging. In this study, we found that insulin resistance, chronic kidney disease stage 3, and osteoporosis at the femur neck were closely associated with sarcopenia in elderly men. These conditions modified to slow down the progression of sarcopenia. INTRODUCTION: Sarcopenia is known to have multiple contributing factors; however, its modifiable risk factors have not yet been determined. The aim of this study was to identify the most influential and modifiable risk factors for sarcopenia in elderly. METHODS: This was a population-based, cross-sectional study using data from the Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV), 2008-2009. This study included 940 men and 1,324 women aged 65 years and older who completed a body composition analysis using dual-energy X-ray absorptiometry. Sarcopenia was defined as an appendicular skeletal muscle mass divided by height(2) of less than 1 standard deviation below the sex-specific mean for a younger reference group. RESULTS: Using univariate analysis, age, body mass index (BMI), homeostasis model assessment for insulin resistance (HOMA-IR), limitations in daily activities, regular exercise, high-risk drinking, family income, osteoporosis, daily energy, and protein intake were associated with sarcopenia in men; age, BMI, limitations in daily activities, regular exercise, occupation, osteoporosis at the total hip, and daily energy intake were associated with sarcopenia in women. In the multivariate logistic regression analysis, HOMA-IR ≥2.5 (odds ratio [OR] for sarcopenia, 2.27; 95 % confidence interval [CI], 1.21-4.25), chronic kidney disease stage 3 (OR, 3.13; 95 % CI, 1.14-8.61), and osteoporosis at the femur neck (OR, 6.83; 95 % CI, 1.08-43.41) were identified as risk factors for sarcopenia in men. CONCLUSIONS: Insulin resistance, chronic kidney disease, and osteoporosis at the femur neck should be modified to prevent the acceleration of skeletal muscle loss in elderly men.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2189~2198-
dc.relation.isPartOfOSTEOPOROSIS INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAbsorptiometry, Photon/methods-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBone Density/physiology-
dc.subject.MESHComorbidity-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHFemur Neck/physiopathology-
dc.subject.MESHHealth Behavior-
dc.subject.MESHHumans-
dc.subject.MESHInsulin Resistance/physiology*-
dc.subject.MESHMale-
dc.subject.MESHNutrition Surveys-
dc.subject.MESHOsteoporosis/complications*-
dc.subject.MESHOsteoporosis/epidemiology-
dc.subject.MESHOsteoporosis/physiopathology-
dc.subject.MESHRenal Insufficiency, Chronic/complications*-
dc.subject.MESHRenal Insufficiency, Chronic/epidemiology-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRisk Factors-
dc.subject.MESHSarcopenia/epidemiology-
dc.subject.MESHSarcopenia/etiology*-
dc.subject.MESHSarcopenia/physiopathology-
dc.subject.MESHSocial Class-
dc.titleEarly-stage chronic kidney disease, insulin resistance, and osteoporosis as risk factors of sarcopenia in aged population: The Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV), 2008–2009-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJ. E. Kim-
dc.contributor.googleauthorY.-h. Lee-
dc.contributor.googleauthorJ. H. Huh-
dc.contributor.googleauthorD. R. Kang-
dc.contributor.googleauthorY. Rhee-
dc.contributor.googleauthorS.-K. Lim-
dc.identifier.doi10.1007/s00198-014-2745-y-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00911-
dc.contributor.localIdA02989-
dc.contributor.localIdA03012-
dc.contributor.localIdA03375-
dc.contributor.localIdA04368-
dc.relation.journalcodeJ02451-
dc.identifier.eissn1433-2965-
dc.identifier.pmid24846317-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00198-014-2745-y-
dc.subject.keywordChronic kidney disease-
dc.subject.keywordInsulin resistance-
dc.subject.keywordOsteoporosis-
dc.subject.keywordSarcopenia-
dc.contributor.alternativeNameKim, Jo Eun-
dc.contributor.alternativeNameLee, Yong Ho-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.alternativeNameLim, Sung Kil-
dc.contributor.alternativeNameHuh, Ji Hye-
dc.contributor.affiliatedAuthorKim, Jo Eun-
dc.contributor.affiliatedAuthorLee, Yong Ho-
dc.contributor.affiliatedAuthorRhee, Yumie-
dc.contributor.affiliatedAuthorLim, Sung Kil-
dc.contributor.affiliatedAuthorHuh, Ji Hye-
dc.rights.accessRightsfree-
dc.citation.volume25-
dc.citation.number9-
dc.citation.startPage2189-
dc.citation.endPage2198-
dc.identifier.bibliographicCitationOSTEOPOROSIS INTERNATIONAL, Vol.25(9) : 2189-2198, 2014-
dc.identifier.rimsid50121-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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