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Role of miRNAs in bone and their potential as therapeutic targets

Authors
 Kyoung Min Kim  ;  Sung-Kil Lim 
Citation
 CURRENT OPINION IN PHARMACOLOGY, Vol.16 : 133-141, 2014 
Journal Title
 CURRENT OPINION IN PHARMACOLOGY 
ISSN
 1471-4892 
Issue Date
2014
MeSH
Animals ; Bone and Bones/metabolism* ; Cell Proliferation ; Humans ; MicroRNAs/metabolism* ; Osteoblasts/cytology ; Osteoblasts/metabolism ; Osteoporosis/drug therapy ; Osteoporosis/genetics ; Osteoporosis/metabolism
Abstract
MicroRNAs (miRNAs) are noncoding, single-stranded RNAs that regulate the expression of target genes by binding their 3'-untranslated region. miRNAs are important regulators of various biological processes, including cellular differentiation, proliferation, apoptosis, and tissue development. Furthermore, aberrant miRNA expression has emerged as an important pathomechanism in various human diseases, including osteoporosis. Thus, the therapeutic potential of miRNA has attracted great interest recently. Here, we focused on the roles of miRNAs in bone homeostasis and the potential of miRNAs as therapeutic targets.
Full Text
http://www.sciencedirect.com/science/article/pii/S1471489214000423
DOI
10.1016/j.coph.2014.05.001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lim, Sung Kil(임승길)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100070
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