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Expression of Reactive Oxygen Species-Related Proteins according to Androgen and HER-2 Status in Estrogen Receptor-Negative Breast Cancer

 Kim J.-Y.  ;  Jung W.H.  ;  Koo J.S. 
 PATHOBIOLOGY, Vol.81(4) : 215-225, 2014 
Journal Title
Issue Date
Breast Neoplasms/classification ; Breast Neoplasms/metabolism* ; Breast Neoplasms/pathology ; Catalase/metabolism ; Female ; Glutathione S-Transferase pi/metabolism ; Humans ; Immunohistochemistry ; Oxidation-Reduction ; Reactive Oxygen Species/metabolism* ; Receptor, ErbB-2/metabolism* ; Receptors, Androgen/metabolism* ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Superoxide Dismutase/metabolism ; Thioredoxin-Disulfide Reductase/metabolism
Androgen receptor ; Breast ; HER-2 ; Redox
Objective: The purpose of the current study is to understand the clinicopathological implications of redox proteins in association with androgen receptor (AR) and HER-2 status in estrogen receptor (ER)-negative breast cancers through evaluation of the expression patterns of redox proteins, such as catalase, thioredoxin reductase (TxNR), glutathione S-transferase π (GSTπ), thioredoxin interacting protein (TxNIP), and manganese superoxide dismutase (MnSOD). Methods: Two hundred cases of ER-negative breast cancer samples were collected as a tissue microarray. Immunohistochemical staining was done for redox-related proteins, after which the resulting data set was organized by AR and HER-2 status. Results: The redox proteins that had a significant association with AR and HER-2 status were tumoral catalase (p < 0.001) and stromal GSTπ (p < 0.001). Tumoral catalase was least expressed in the AR-/HER-2- group, while stromal GSTπ was least expressed in both the AR+/HER-2- and the AR-/HER-2- groups. Stromal GSTπ was highly expressed in HER-2 positive groups (p < 0.001). Stromal GSTπ negativity and tumoral MnSOD positivity were associated with a shorter disease-free survival (p = 0.041 and p = 0.007, respectively) in univariate analysis. Conclusion: ER-negative breast cancers showed different expressions of redox-related proteins according to AR and HER-2 status. Catalase expression was high in AR-negative groups, while stromal GSTπ expression was high in HER-2-positive groups.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Jung, Woo Hee(정우희)
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