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Expression of Reactive Oxygen Species-Related Proteins according to Androgen and HER-2 Status in Estrogen Receptor-Negative Breast Cancer

DC FieldValueLanguage
dc.contributor.author구자승-
dc.contributor.author정우희-
dc.date.accessioned2015-01-06T17:28:08Z-
dc.date.available2015-01-06T17:28:08Z-
dc.date.issued2014-
dc.identifier.issn1015-2008-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100036-
dc.description.abstractObjective: The purpose of the current study is to understand the clinicopathological implications of redox proteins in association with androgen receptor (AR) and HER-2 status in estrogen receptor (ER)-negative breast cancers through evaluation of the expression patterns of redox proteins, such as catalase, thioredoxin reductase (TxNR), glutathione S-transferase π (GSTπ), thioredoxin interacting protein (TxNIP), and manganese superoxide dismutase (MnSOD). Methods: Two hundred cases of ER-negative breast cancer samples were collected as a tissue microarray. Immunohistochemical staining was done for redox-related proteins, after which the resulting data set was organized by AR and HER-2 status. Results: The redox proteins that had a significant association with AR and HER-2 status were tumoral catalase (p < 0.001) and stromal GSTπ (p < 0.001). Tumoral catalase was least expressed in the AR-/HER-2- group, while stromal GSTπ was least expressed in both the AR+/HER-2- and the AR-/HER-2- groups. Stromal GSTπ was highly expressed in HER-2 positive groups (p < 0.001). Stromal GSTπ negativity and tumoral MnSOD positivity were associated with a shorter disease-free survival (p = 0.041 and p = 0.007, respectively) in univariate analysis. Conclusion: ER-negative breast cancers showed different expressions of redox-related proteins according to AR and HER-2 status. Catalase expression was high in AR-negative groups, while stromal GSTπ expression was high in HER-2-positive groups.-
dc.description.statementOfResponsibilityopen-
dc.format.extent215~225-
dc.relation.isPartOfPATHOBIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBreast Neoplasms/classification-
dc.subject.MESHBreast Neoplasms/metabolism*-
dc.subject.MESHBreast Neoplasms/pathology-
dc.subject.MESHCatalase/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHGlutathione S-Transferase pi/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHOxidation-Reduction-
dc.subject.MESHReactive Oxygen Species/metabolism*-
dc.subject.MESHReceptor, ErbB-2/metabolism*-
dc.subject.MESHReceptors, Androgen/metabolism*-
dc.subject.MESHReceptors, Estrogen/metabolism-
dc.subject.MESHReceptors, Progesterone/metabolism-
dc.subject.MESHSuperoxide Dismutase/metabolism-
dc.subject.MESHThioredoxin-Disulfide Reductase/metabolism-
dc.titleExpression of Reactive Oxygen Species-Related Proteins according to Androgen and HER-2 Status in Estrogen Receptor-Negative Breast Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorKim J.-Y.-
dc.contributor.googleauthorJung W.H.-
dc.contributor.googleauthorKoo J.S.-
dc.identifier.doi10.1159/000366021-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00198-
dc.contributor.localIdA03671-
dc.relation.journalcodeJ02470-
dc.identifier.eissn1423-0291-
dc.identifier.pmid25322848-
dc.identifier.urlhttp://www.karger.com/Article/FullText/366021-
dc.subject.keywordAndrogen receptor-
dc.subject.keywordBreast-
dc.subject.keywordHER-2-
dc.subject.keywordRedox-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameJung, Woo Hee-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorJung, Woo Hee-
dc.contributor.affiliatedAuthor구자승-
dc.rights.accessRightsfree-
dc.citation.volume81-
dc.citation.number4-
dc.citation.startPage215-
dc.citation.endPage225-
dc.identifier.bibliographicCitationPATHOBIOLOGY, Vol.81(4) : 215-225, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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