3-Diethylaminopropyl-bearing glycol chitosan as a protein drug carrier.

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Authors: Hye Jung Baik ; Nam Muk Oh ; Young Taik Oh ; Na Young Yoo ; So Young Park ; Kyung Taek Oh ; Yu Seok Youn ; Eun Seong Lee

MeSH: 1-Propanol/chemistry* ; Amines/chemistry* ; Animals ; Cattle ; Cell Line, Tumor ; Chitosan/chemistry* ; DrugDelivery Systems*/methods ; Female ; Flow Cytometry ; Humans ; Mice ; Mice, Nude ; Models, Molecular ; Molecular Structure ; Neoplasms/drugtherapy ; Polyethylene Glycols/chemistry ; Polyethyleneimine/chemistry ; Serum Albumin, Bovine/chemistry*

Keywords: Polysaccharidic nanogels ; Glycol chitosan ; Bovine serum albumin ; Ph-sensitivity

Abstract: Polysaccharidic nanogels were fabricated with bovine serum albumin (BSA) and a glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups. These nanogels were investigated to evaluate their cellular uptake in HeLa cells and in vivo fate in nude mice tumor model. Unlike free BSA, GCS-g-DEAP/BSA nanogels improved cellular uptake of BSA. Furthermore, this system led to an enhanced blood circulation and a high accumulation of BSA in the tumor site. Our collective results strongly support that GCS-g-DEAP/BSA nanogel is a potential carrier system for high molecular weight proteins.

Full Text: http://www.sciencedirect.com/science/article/pii/S0927776511000373

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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