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3-Diethylaminopropyl-bearing glycol chitosan as a protein drug carrier.

Authors
 Hye Jung Baik  ;  Nam Muk Oh  ;  Young Taik Oh  ;  Na Young Yoo  ;  So Young Park  ;  Kyung Taek Oh  ;  Yu Seok Youn  ;  Eun Seong Lee 
Citation
 COLLOIDS AND SURFACES B-BIOINTERFACES, Vol.84(2) : 585-590, 2011 
Journal Title
 COLLOIDS AND SURFACES B-BIOINTERFACES 
ISSN
 0927-7765 
Issue Date
2011
MeSH
1-Propanol/chemistry* ; Amines/chemistry* ; Animals ; Cattle ; Cell Line, Tumor ; Chitosan/chemistry* ; Drug Delivery Systems*/methods ; Female ; Flow Cytometry ; Humans ; Mice ; Mice, Nude ; Models, Molecular ; Molecular Structure ; Neoplasms/drug therapy ; Polyethylene Glycols/chemistry ; Polyethyleneimine/chemistry ; Serum Albumin, Bovine/chemistry*
Keywords
Polysaccharidic nanogels ; Glycol chitosan ; Bovine serum albumin ; Ph-sensitivity
Abstract
Polysaccharidic nanogels were fabricated with bovine serum albumin (BSA) and a glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups. These nanogels were investigated to evaluate their cellular uptake in HeLa cells and in vivo fate in nude mice tumor model. Unlike free BSA, GCS-g-DEAP/BSA nanogels improved cellular uptake of BSA. Furthermore, this system led to an enhanced blood circulation and a high accumulation of BSA in the tumor site. Our collective results strongly support that GCS-g-DEAP/BSA nanogel is a potential carrier system for high molecular weight proteins.
Full Text
http://www.sciencedirect.com/science/article/pii/S0927776511000373
DOI
10.1016/j.colsurfb.2011.01.017
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94371
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