Prognostic effect of stromal lymphocyte infiltration in thymic carcinoma

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Authors: Hyo Sup Shim ; Chun Sung Byun ; Mi Kyung Bae ; Chang Young Lee ; In Kyu Park ; Dae Joon Kim ; Kyung Young Chung ; Jin Gu Lee

MeSH: Adult ; Aged ; Antigens, CD/metabolism ; Carcinoma/diagnosis* ; Carcinoma/mortality ; Carcinoma/pathology* ; Carcinoma/physiopathology ; Carcinoma/surgery ; Cell Count ; Cell Movement/immunology ; Connective Tissue/immunology ; Connective Tissue/pathology ; Female ; Humans ; Immunohistochemistry ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Lymphocytes, Tumor-Infiltrating/pathology* ; Male ; Middle Aged ; Prognosis ; Thymectomy ; Thymus Neoplasms/diagnosis* ; Thymus Neoplasms/mortality ; Thymus Neoplasms/pathology* ; Thymus Neoplasms/physiopathology ; Thymus Neoplasms/surgery ; Tumor Escape ; Tumor Microenvironment/immunology

Abstract: BACKGROUND: The purpose of this study was to clarify the relationship between the tumor infiltrating lymphocytes and clinical outcome in patients with thymic carcinoma.

METHODS: Tissue specimens from 32 patients who underwent surgical resection for thymic carcinoma were immunohistochemically analyzed for CD4, CD8 and CD20 expression.

RESULTS: Tumor-infiltrating lymphocytes were generally more abundant in the stroma. The patients with low CD4+ lymphocytes (p=0.037) and low CD20+ lymphocytes (p=0.045) within tumor stroma showed poor survival. Furthermore, concurrent low levels of CD4+ and CD20+ (p=0.014), CD8+ and CD20+ (p=0.025), and, CD4+, CD8+, and CD20+ (p=0.025) in tumor stroma were significantly associated with poor prognosis when compared to the others group.

CONCLUSION: Our results indicate that infiltrating CD4+, CD8+, and CD20+ lymphocytes in cancer stroma may cooperate to suppress cancer progression and their presence together appear to be prognostic factor in thymic carcinoma.

Full Text: http://www.sciencedirect.com/science/article/pii/S0169500211001693

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

Yonsei Authors: Kim, Dae Joon(김대준)
Park, In Kyu(박인규)
Bae, Mi Kyung(배미경)
Byun, Chun Sung(변천성)
Lee, Jin Gu(이진구)
Lee, Chang Young(이창영)
Chung, Kyung Young(정경영)

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