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Prognostic effect of stromal lymphocyte infiltration in thymic carcinoma

Title
 Prognostic effect of stromal lymphocyte infiltration in thymic carcinoma
Authors
 Hyo Sup Shim; Chun Sung Byun; Jin Gu Lee; Kyung Young Chung; Dae Joon Kim; In Kyu Park; Chang Young Lee; Mi Kyung Bae
Issue Date
2011
Journal Title
 Lung Cancer
ISSN
 0169-5002
Citation
 Lung Cancer, Vol.74(2) : 338~343, 2011
Abstract
BACKGROUND: The purpose of this study was to clarify the relationship between the tumor infiltrating lymphocytes and clinical outcome in patients with thymic carcinoma. METHODS: Tissue specimens from 32 patients who underwent surgical resection for thymic carcinoma were immunohistochemically analyzed for CD4, CD8 and CD20 expression. RESULTS: Tumor-infiltrating lymphocytes were generally more abundant in the stroma. The patients with low CD4+ lymphocytes (p=0.037) and low CD20+ lymphocytes (p=0.045) within tumor stroma showed poor survival. Furthermore, concurrent low levels of CD4+ and CD20+ (p=0.014), CD8+ and CD20+ (p=0.025), and, CD4+, CD8+, and CD20+ (p=0.025) in tumor stroma were significantly associated with poor prognosis when compared to the others group. CONCLUSION: Our results indicate that infiltrating CD4+, CD8+, and CD20+ lymphocytes in cancer stroma may cooperate to suppress cancer progression and their presence together appear to be prognostic factor in thymic carcinoma.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94083
DOI
10.1016/j.lungcan.2011.03.008
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
1. 연구논문 > 1. College of Medicine > Dept. of Thoracic & Cardiovascular Surgery
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0169500211001693
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