Cited 5 times in
Prognostic effect of stromal lymphocyte infiltration in thymic carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김대준 | - |
dc.contributor.author | 박인규 | - |
dc.contributor.author | 배미경 | - |
dc.contributor.author | 변천성 | - |
dc.contributor.author | 이진구 | - |
dc.contributor.author | 이창영 | - |
dc.contributor.author | 정경영 | - |
dc.date.accessioned | 2014-12-20T17:10:01Z | - |
dc.date.available | 2014-12-20T17:10:01Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0169-5002 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94083 | - |
dc.description.abstract | BACKGROUND: The purpose of this study was to clarify the relationship between the tumor infiltrating lymphocytes and clinical outcome in patients with thymic carcinoma. METHODS: Tissue specimens from 32 patients who underwent surgical resection for thymic carcinoma were immunohistochemically analyzed for CD4, CD8 and CD20 expression. RESULTS: Tumor-infiltrating lymphocytes were generally more abundant in the stroma. The patients with low CD4+ lymphocytes (p=0.037) and low CD20+ lymphocytes (p=0.045) within tumor stroma showed poor survival. Furthermore, concurrent low levels of CD4+ and CD20+ (p=0.014), CD8+ and CD20+ (p=0.025), and, CD4+, CD8+, and CD20+ (p=0.025) in tumor stroma were significantly associated with poor prognosis when compared to the others group. CONCLUSION: Our results indicate that infiltrating CD4+, CD8+, and CD20+ lymphocytes in cancer stroma may cooperate to suppress cancer progression and their presence together appear to be prognostic factor in thymic carcinoma. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | LUNG CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antigens, CD/metabolism | - |
dc.subject.MESH | Carcinoma/diagnosis* | - |
dc.subject.MESH | Carcinoma/mortality | - |
dc.subject.MESH | Carcinoma/pathology* | - |
dc.subject.MESH | Carcinoma/physiopathology | - |
dc.subject.MESH | Carcinoma/surgery | - |
dc.subject.MESH | Cell Count | - |
dc.subject.MESH | Cell Movement/immunology | - |
dc.subject.MESH | Connective Tissue/immunology | - |
dc.subject.MESH | Connective Tissue/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Lymphocytes, Tumor-Infiltrating/immunology | - |
dc.subject.MESH | Lymphocytes, Tumor-Infiltrating/metabolism | - |
dc.subject.MESH | Lymphocytes, Tumor-Infiltrating/pathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Thymectomy | - |
dc.subject.MESH | Thymus Neoplasms/diagnosis* | - |
dc.subject.MESH | Thymus Neoplasms/mortality | - |
dc.subject.MESH | Thymus Neoplasms/pathology* | - |
dc.subject.MESH | Thymus Neoplasms/physiopathology | - |
dc.subject.MESH | Thymus Neoplasms/surgery | - |
dc.subject.MESH | Tumor Escape | - |
dc.subject.MESH | Tumor Microenvironment/immunology | - |
dc.title | Prognostic effect of stromal lymphocyte infiltration in thymic carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Hyo Sup Shim | - |
dc.contributor.googleauthor | Chun Sung Byun | - |
dc.contributor.googleauthor | Mi Kyung Bae | - |
dc.contributor.googleauthor | Chang Young Lee | - |
dc.contributor.googleauthor | In Kyu Park | - |
dc.contributor.googleauthor | Dae Joon Kim | - |
dc.contributor.googleauthor | Kyung Young Chung | - |
dc.contributor.googleauthor | Jin Gu Lee | - |
dc.identifier.doi | 10.1016/j.lungcan.2011.03.008 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00368 | - |
dc.contributor.localId | A01625 | - |
dc.contributor.localId | A01792 | - |
dc.contributor.localId | A01859 | - |
dc.contributor.localId | A02219 | - |
dc.contributor.localId | A03225 | - |
dc.contributor.localId | A03245 | - |
dc.contributor.localId | A03571 | - |
dc.relation.journalcode | J02174 | - |
dc.identifier.eissn | 1872-8332 | - |
dc.identifier.pmid | 21492951 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0169500211001693 | - |
dc.subject.keyword | Thymic carcinoma | - |
dc.subject.keyword | CD4+ | - |
dc.subject.keyword | CD8+ | - |
dc.subject.keyword | CD20+ | - |
dc.subject.keyword | Lymphocyte | - |
dc.contributor.alternativeName | Kim, Dae Joon | - |
dc.contributor.alternativeName | Park, In Kyu | - |
dc.contributor.alternativeName | Bae, Mi Kyung | - |
dc.contributor.alternativeName | Byun, Chun Sung | - |
dc.contributor.alternativeName | Lee, Jin Gu | - |
dc.contributor.alternativeName | Lee, Chang Young | - |
dc.contributor.alternativeName | Chung, Kyung Young | - |
dc.contributor.affiliatedAuthor | Kim, Dae Joon | - |
dc.contributor.affiliatedAuthor | Park, In Kyu | - |
dc.contributor.affiliatedAuthor | Bae, Mi Kyung | - |
dc.contributor.affiliatedAuthor | Byun, Chun Sung | - |
dc.contributor.affiliatedAuthor | Lee, Jin Gu | - |
dc.contributor.affiliatedAuthor | Lee, Chang Young | - |
dc.contributor.affiliatedAuthor | Chung, Kyung Young | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 74 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 338 | - |
dc.citation.endPage | 343 | - |
dc.identifier.bibliographicCitation | LUNG CANCER, Vol.74(2) : 338-343, 2011 | - |
dc.identifier.rimsid | 27225 | - |
dc.type.rims | ART | - |
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