Cited 0 times in

Association between Eosinophilic Airway Inflammation and Persistent Airflow Limitation

Title
 Association between Eosinophilic Airway Inflammation and Persistent Airflow Limitation 
Authors
 Yong Ju Lee ; Hyun Hee Lee ; Kyu Earn Kim ; Myung Hyun Sohn ; Kyung Won Kim ; Hye Mi Jee ; Bong Seok Choi 
Issue Date
2013
Journal Title
 Journal of Asthma 
ISSN
 0277-0903 
Citation
 Journal of Asthma, Vol.50(4) : 342~346, 2013 
Abstract
OBJECTIVE: We aimed to evaluate the association between eosinophilic inflammation in induced sputum and pulmonary function and persistent airflow limitation in children. METHODS: A total of 92 asthmatic children and 72 controls were enrolled in this study. Eosinophil count (%) and eosinophil cationic protein (ECP) levels were measured in induced sputum. We performed spirometry and a methacholine challenge test, and measured total eosinophil count, total serum IgE, and serum ECP in all subjects. RESULTS: Asthmatic children had significantly higher levels of sputum eosinophils (9% vs. 0%; P < 0.001) and sputum ECP (2.3 ± 0.7 vs. 1.6 ± 0.6 log µg/L, p < .001) than controls. Sputum ECP levels showed a significant negative correlation with post-bronchodilator (post-BD) FEV(1) (r = -0.307; p = .001) and post-BD FEV(1)/FVC (r = -0.286; p = .002), whereas sputum eosinophils showed no correlation with post-BD FEV(1) and post-BD FEV(1)/FVC. However, no significant differences in sputum ECP and sputum eosinophil counts were observed in asthmatic children with and without persistent airflow limitation. CONCLUSIONS: Our findings suggest that sputum eosinophilic inflammation, especially ECP, is associated with pulmonary function and persistent airflow limitation, which is manifested by low post-BD FEV(1)/FVC.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/87229
DOI
10.3109/02770903.2013.776074
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pediatrics
Yonsei Authors
사서에게 알리기
  feedback
Link
 http://informahealthcare.com/doi/abs/10.3109/02770903.2013.776074
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse