Cited 4 times in
Association between Eosinophilic Airway Inflammation and Persistent Airflow Limitation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경원 | - |
dc.contributor.author | 김규언 | - |
dc.contributor.author | 손명현 | - |
dc.date.accessioned | 2014-12-18T08:56:17Z | - |
dc.date.available | 2014-12-18T08:56:17Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0277-0903 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87229 | - |
dc.description.abstract | OBJECTIVE: We aimed to evaluate the association between eosinophilic inflammation in induced sputum and pulmonary function and persistent airflow limitation in children. METHODS: A total of 92 asthmatic children and 72 controls were enrolled in this study. Eosinophil count (%) and eosinophil cationic protein (ECP) levels were measured in induced sputum. We performed spirometry and a methacholine challenge test, and measured total eosinophil count, total serum IgE, and serum ECP in all subjects. RESULTS: Asthmatic children had significantly higher levels of sputum eosinophils (9% vs. 0%; P < 0.001) and sputum ECP (2.3 ± 0.7 vs. 1.6 ± 0.6 log µg/L, p < .001) than controls. Sputum ECP levels showed a significant negative correlation with post-bronchodilator (post-BD) FEV(1) (r = -0.307; p = .001) and post-BD FEV(1)/FVC (r = -0.286; p = .002), whereas sputum eosinophils showed no correlation with post-BD FEV(1) and post-BD FEV(1)/FVC. However, no significant differences in sputum ECP and sputum eosinophil counts were observed in asthmatic children with and without persistent airflow limitation. CONCLUSIONS: Our findings suggest that sputum eosinophilic inflammation, especially ECP, is associated with pulmonary function and persistent airflow limitation, which is manifested by low post-BD FEV(1)/FVC. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF ASTHMA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Asthma/metabolism | - |
dc.subject.MESH | Asthma/pathology* | - |
dc.subject.MESH | Bronchial Provocation Tests | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cell Count | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Eosinophil Cationic Protein/metabolism | - |
dc.subject.MESH | Eosinophils/immunology* | - |
dc.subject.MESH | Eosinophils/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation/metabolism | - |
dc.subject.MESH | Inflammation/pathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Methacholine Chloride/metabolism | - |
dc.subject.MESH | Respiratory Function Tests | - |
dc.subject.MESH | Sputum/cytology | - |
dc.subject.MESH | Sputum/immunology* | - |
dc.subject.MESH | Statistics, Nonparametric | - |
dc.title | Association between Eosinophilic Airway Inflammation and Persistent Airflow Limitation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Yong Ju Lee | - |
dc.contributor.googleauthor | Hyun Hee Lee | - |
dc.contributor.googleauthor | Bong Seok Choi | - |
dc.contributor.googleauthor | Hye Mi Jee | - |
dc.contributor.googleauthor | Kyung Won Kim | - |
dc.contributor.googleauthor | Myung Hyun Sohn | - |
dc.contributor.googleauthor | Kyu Earn Kim | - |
dc.identifier.doi | 10.3109/02770903.2013.776074 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00303 | - |
dc.contributor.localId | A00327 | - |
dc.contributor.localId | A01967 | - |
dc.relation.journalcode | J01250 | - |
dc.identifier.eissn | 1532-4303 | - |
dc.identifier.pmid | 23414249 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.3109/02770903.2013.776074 | - |
dc.subject.keyword | airway obstruction | - |
dc.subject.keyword | asthma | - |
dc.subject.keyword | child | - |
dc.subject.keyword | eosinophils | - |
dc.subject.keyword | eosinophil cationic protein | - |
dc.contributor.alternativeName | Kim, Kyung Won | - |
dc.contributor.alternativeName | Kim, Kyu Earn | - |
dc.contributor.alternativeName | Son, Myung Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Won | - |
dc.contributor.affiliatedAuthor | Kim, Kyu Earn | - |
dc.contributor.affiliatedAuthor | Son, Myung Hyun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 50 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 342 | - |
dc.citation.endPage | 346 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ASTHMA, Vol.50(4) : 342-346, 2013 | - |
dc.identifier.rimsid | 32913 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.