6 201

Cited 3 times in

Association between Eosinophilic Airway Inflammation and Persistent Airflow Limitation

 Yong Ju Lee  ;  Hyun Hee Lee  ;  Bong Seok Choi  ;  Hye Mi Jee  ;  Kyung Won Kim  ;  Myung Hyun Sohn  ;  Kyu Earn Kim 
 Journal of Asthma, Vol.50(4) : 342-346, 2013 
Journal Title
 Journal of Asthma 
Issue Date
Asthma/metabolism ; Asthma/pathology* ; Bronchial Provocation Tests ; Case-Control Studies ; Cell Count ; Child ; Eosinophil Cationic Protein/metabolism ; Eosinophils/immunology* ; Eosinophils/pathology ; Female ; Humans ; Inflammation/metabolism ; Inflammation/pathology* ; Male ; Methacholine Chloride/metabolism ; Respiratory Function Tests ; Sputum/cytology ; Sputum/immunology* ; Statistics, Nonparametric
airway obstruction ; asthma ; child ; eosinophils ; eosinophil cationic protein
OBJECTIVE: We aimed to evaluate the association between eosinophilic inflammation in induced sputum and pulmonary function and persistent airflow limitation in children. METHODS: A total of 92 asthmatic children and 72 controls were enrolled in this study. Eosinophil count (%) and eosinophil cationic protein (ECP) levels were measured in induced sputum. We performed spirometry and a methacholine challenge test, and measured total eosinophil count, total serum IgE, and serum ECP in all subjects. RESULTS: Asthmatic children had significantly higher levels of sputum eosinophils (9% vs. 0%; P < 0.001) and sputum ECP (2.3 ± 0.7 vs. 1.6 ± 0.6 log µg/L, p < .001) than controls. Sputum ECP levels showed a significant negative correlation with post-bronchodilator (post-BD) FEV(1) (r = -0.307; p = .001) and post-BD FEV(1)/FVC (r = -0.286; p = .002), whereas sputum eosinophils showed no correlation with post-BD FEV(1) and post-BD FEV(1)/FVC. However, no significant differences in sputum ECP and sputum eosinophil counts were observed in asthmatic children with and without persistent airflow limitation. CONCLUSIONS: Our findings suggest that sputum eosinophilic inflammation, especially ECP, is associated with pulmonary function and persistent airflow limitation, which is manifested by low post-BD FEV(1)/FVC.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.