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Association between Eosinophilic Airway Inflammation and Persistent Airflow Limitation

Authors
 Yong Ju Lee  ;  Hyun Hee Lee  ;  Bong Seok Choi  ;  Hye Mi Jee  ;  Kyung Won Kim  ;  Myung Hyun Sohn  ;  Kyu Earn Kim 
Citation
 Journal of Asthma, Vol.50(4) : 342-346, 2013 
Journal Title
 Journal of Asthma 
ISSN
 0277-0903 
Issue Date
2013
Abstract
OBJECTIVE: We aimed to evaluate the association between eosinophilic inflammation in induced sputum and pulmonary function and persistent airflow limitation in children. METHODS: A total of 92 asthmatic children and 72 controls were enrolled in this study. Eosinophil count (%) and eosinophil cationic protein (ECP) levels were measured in induced sputum. We performed spirometry and a methacholine challenge test, and measured total eosinophil count, total serum IgE, and serum ECP in all subjects. RESULTS: Asthmatic children had significantly higher levels of sputum eosinophils (9% vs. 0%; P < 0.001) and sputum ECP (2.3 ± 0.7 vs. 1.6 ± 0.6 log µg/L, p < .001) than controls. Sputum ECP levels showed a significant negative correlation with post-bronchodilator (post-BD) FEV(1) (r = -0.307; p = .001) and post-BD FEV(1)/FVC (r = -0.286; p = .002), whereas sputum eosinophils showed no correlation with post-BD FEV(1) and post-BD FEV(1)/FVC. However, no significant differences in sputum ECP and sputum eosinophil counts were observed in asthmatic children with and without persistent airflow limitation. CONCLUSIONS: Our findings suggest that sputum eosinophilic inflammation, especially ECP, is associated with pulmonary function and persistent airflow limitation, which is manifested by low post-BD FEV(1)/FVC.
Full Text
http://informahealthcare.com/doi/abs/10.3109/02770903.2013.776074
DOI
10.3109/02770903.2013.776074
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
김경원(Kim, Kyung Won) ORCID logo https://orcid.org/0000-0003-4529-6135
김규언(Kim, Kyu Earn)
손명현(Sohn, Myung Hyun) ORCID logo https://orcid.org/0000-0002-2478-487X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87229
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