1 714

Cited 11 times in

Prospective Measurement of Urinary Microalbumin in Living Kidney Donor Nephrectomy: Toward Understanding the Renal Functional Recovery Period

Authors
 Young Eun Yoon  ;  Kwang Suk Lee  ;  Kyung Hwa Choi  ;  Kwang Hyun Kim  ;  Seung Choul Yang  ;  Woong Kyu Han 
Citation
 JOURNAL OF UROLOGY, Vol.192(4) : 1172-1177, 2014 
Journal Title
JOURNAL OF UROLOGY
ISSN
 0022-5347 
Issue Date
2014
MeSH
Adult ; Albuminuria/physiopathology ; Albuminuria/therapy* ; Biomarkers/urine* ; Creatine/urine ; Delayed Graft Function/diagnosis ; Delayed Graft Function/urine ; Female ; Follow-Up Studies ; Glomerular Filtration Rate/physiology* ; Humans ; Living Donors* ; Male ; Nephrectomy* ; Postoperative Period ; Preoperative Care/methods* ; Prognosis ; Prospective Studies ; ROC Curve ; Recovery of Function* ; Time Factors
Keywords
albuminuria ; delayed graft function ; kidney transplantation ; living donors ; nephrectomy
Abstract
PURPOSE:
We determined the clinical implications of perioperative urinary microalbumin excretion in relation to renal function after living donor nephrectomy.
MATERIALS AND METHODS:
Between August 2010 and January 2013, 259 donors undergoing live donor nephrectomy were enrolled in the study. The donor urinary albumin-to-creatinine ratio was measured perioperatively, and changes in perioperative urinary albumin-to-creatinine ratio and the implications of preoperative microalbuminuria (urinary albumin-to-creatinine ratio 30 mg/gm or greater) were investigated. The relationships between perioperative urinary albumin-to-creatinine ratio and recovery of renal function and implantation biopsy histology were also analyzed.
RESULTS:
Mean ± SD preoperative urinary albumin-to-creatinine ratio was 7.1±12.7 mg/gm. The urinary albumin-to-creatinine ratio was increased after 1 day (24.7±18.9 mg/gm, p <0.001) and stabilized after 1 month (10.3±10.7 mg/gm, p <0.001). Preoperative microalbuminuria was not associated with perioperative estimated glomerular filtration rate during a followup period of 6 months but was associated with histological abnormalities. Donors with a higher urinary albumin-to-creatinine ratio before donation, even in the normal range, consistently had an increased postoperative urinary albumin-to-creatinine ratio. A ROC curve analysis showed that age, preoperative estimated glomerular filtration rate and 1-month postoperative urinary albumin-to-creatinine ratio were highly predictive of delayed recovery of renal function (AUC 0.884, p <0.001). The 1-month postoperative urinary albumin-to-creatinine ratio was associated with delayed recovery of renal function (OR 1.05 for each 0.1 mg/gm increase, p=0.021).
CONCLUSIONS:
Donors with higher preoperative urinary albumin-to-creatinine ratio levels require close observation because there is a greater possibility of microalbuminuria developing after donation even if the ratio is within the normal range. A higher urinary albumin-to-creatinine ratio was also associated with delayed recovery of renal function and histological abnormalities.
Full Text
http://www.sciencedirect.com/science/article/pii/S0022534714031954
DOI
10.1016/j.juro.2014.03.106
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kwang Hyun(김광현)
Yang, Seung Choul(양승철)
Yoon, Young Eun(윤영은)
Lee, Kwang Suk(이광석) ORCID logo https://orcid.org/0000-0002-7961-8393
Choi, Kyung Hwa(최경화)
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99999
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links