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Cited 8 times in

Effect of Combined Bevacizumab and Temozolomide Treatment on Intramedullary Spinal Cord Tumor

DC FieldValueLanguage
dc.contributor.author윤도흠-
dc.contributor.author하윤-
dc.contributor.author곽소정-
dc.contributor.author김긍년-
dc.contributor.author안성수-
dc.contributor.author양문술-
dc.date.accessioned2015-01-06T17:25:34Z-
dc.date.available2015-01-06T17:25:34Z-
dc.date.issued2014-
dc.identifier.issn0362-2436-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99956-
dc.description.abstractSTUDY DESIGN: C6 glioma cells and an intramedullary spinal cord tumor model were used to evaluate the effect of bevacizumab (Avastin) or temozolomide (TMZ). OBJECTIVE: In this study, we hypothesized that treatment with bevacizumab accelerates the therapeutic effect of TMZ on intramedullary gliomas in an animal model. SUMMARY OF BACKGROUND DATA: Recently therapies for the management of intramedullary malignant gliomas include surgery, chemotherapy, and radiotherapy. Concurrent or adjuvant TMZ has been considered an emerging new treatment for intramedullary malignant gliomas; however, high-dose application of TMZ has limitation of side effect. METHODS: C6 glioma cells were injected into the T5 level of the spinal cord, and TMZ and bevacizumab were administered 5 days after C6 inoculation (n = 7 for each group). Tumor size was analyzed using histology and magnetic resonance imaging at 13 days after tumor inoculation. RESULTS: Histological analyses and magnetic resonance imaging findings showed that combined treatment with TMZ and bevacizumab reduced tumor mass. The tumor volume of control group was 2.8-fold higher than combined therapy (P < 0.05). Neurological outcomes demonstrated that combined therapy improved hind limb function more than TMZ-alone group or control group (P < 0.05). CONCLUSION: This study shows that bevacizumab could be useful in combination with TMZ to increase the therapeutic benefits of TMZ for intramedullary spinal cord tumors. LEVEL OF EVIDENCE: N/A.-
dc.description.statementOfResponsibilityopen-
dc.format.extentE65~E73-
dc.relation.isPartOfSPINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAntibodies, Monoclonal, Humanized/administration & dosage-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/administration & dosage*-
dc.subject.MESHBevacizumab-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHDacarbazine/administration & dosage-
dc.subject.MESHDacarbazine/analogs & derivatives-
dc.subject.MESHMale-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHSpinal Cord Neoplasms/drug therapy*-
dc.subject.MESHSpinal Cord Neoplasms/pathology*-
dc.subject.MESHTreatment Outcome-
dc.titleEffect of Combined Bevacizumab and Temozolomide Treatment on Intramedullary Spinal Cord Tumor-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학)-
dc.contributor.googleauthorSo-Jung Gwak-
dc.contributor.googleauthorSung Su An-
dc.contributor.googleauthorMoon Sul Yang-
dc.contributor.googleauthorEunhae Joe-
dc.contributor.googleauthorDong-Hyun Kim-
dc.contributor.googleauthorDo Heum Yoon-
dc.contributor.googleauthorKeung Nyun Kim-
dc.contributor.googleauthorYoon Ha-
dc.identifier.doi10.1097/BRS.0000000000000070-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02546-
dc.contributor.localIdA04255-
dc.contributor.localIdA00168-
dc.contributor.localIdA00331-
dc.contributor.localIdA02235-
dc.contributor.localIdA02286-
dc.relation.journalcodeJ02674-
dc.identifier.eissn1528-1159-
dc.identifier.pmid24158177-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00007632-201401150-00002&LSLINK=80&D=ovft-
dc.subject.keywordbevacizumab-
dc.subject.keywordtemozolomide-
dc.subject.keywordintramedullary spinal cord tumor-
dc.contributor.alternativeNameYoon, Do Heum-
dc.contributor.alternativeNameHa, Yoon-
dc.contributor.alternativeNameGwak, So Jung-
dc.contributor.alternativeNameKim, Keung Nyun-
dc.contributor.alternativeNameAn, Sung Su-
dc.contributor.alternativeNameYang, Moon Sool-
dc.contributor.affiliatedAuthorYoon, Do Heum-
dc.contributor.affiliatedAuthorHa, Yoon-
dc.contributor.affiliatedAuthorGwak, So Jung-
dc.contributor.affiliatedAuthorKim, Keung Nyun-
dc.contributor.affiliatedAuthorAn, Sung Su-
dc.contributor.affiliatedAuthorYang, Moon Sool-
dc.rights.accessRightsfree-
dc.citation.volume39-
dc.citation.number2-
dc.citation.startPage65-
dc.citation.endPage73-
dc.identifier.bibliographicCitationSPINE, Vol.39(2) : 65-73, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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