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Assessment of predictive markers for placental inflammatory response in preterm births

Authors
 Min-A Kim  ;  You Sun Lee  ;  Kyung Seo 
Citation
 PLOS ONE, Vol.9(10) : e107880, 2014 
Journal Title
PLOS ONE
Issue Date
2014
MeSH
Adult ; Biomarkers/blood ; Biomarkers/metabolism ; C-Reactive Protein/metabolism ; Chorioamnionitis/metabolism ; Female ; Humans ; Inflammation/metabolism* ; Leukocyte Count ; Placenta Diseases/metabolism* ; Placenta Diseases/pathology ; Pregnancy ; Pregnancy Outcome ; Premature Birth/blood ; Premature Birth/diagnosis ; Premature Birth/metabolism* ; Premature Birth/mortality ; Prognosis ; Retrospective Studies
Abstract
Placental inflammatory response (PIR) is associated with adverse neonatal outcomes such as sepsis, cerebral palsy, low birth weight, preterm birth, and neonatal mortality. However, there is an urgent need for noninvasive and sensitive biomarkers for prediction of PIR. In this study, we evaluated the clinical usefulness of maternal serum inflammatory markers for prediction of PIR in women with impending preterm birth. We conducted a retrospective cohort study of 483 patients who delivered preterm neonates. Serum levels of leukocyte differential counts, C-reactive protein (CRP), and neutrophil to lymphocyte ratio (NLR) were compared between women with no placental inflammation and women with PIR. The mean neutrophil counts, CRP levels, and NLR in both the patients with histologic chorioamnionitis (HCA) alone and those with HCA with funisitis were significantly higher than those in women with no placental inflammation. Compared to leukocyte subset or CRP, NLR in women with funisitis was significantly higher than in women with HCA alone and showed higher predictive accuracy, along with 71.4% sensitivity, 77.9% specificity, 80.7% positive predictive value, and 67.8% negative predictive value for prediction of PIR. On Kaplan-Meier survival analysis, women with both an elevated level of CRP and a high NLR had a shorter admission-to-delivery interval compared to women with either an elevated level of CRP or a high NLR alone. NLR may be a predictive marker of PIR and could be used as a cost-effective parameter for identifying women at risk of PIR.
Files in This Item:
T201403464.pdf Download
DOI
10.1371/journal.pone.0107880
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min A(김민아)
Seo, Kyung(서경)
Lee, You Sun(이유선)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99930
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