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Clinical outcomes after sentinellymph node biopsy in clinically node-negative breast cancer patients

Authors
 Hee Ji Han  ;  Ju Ree Kim  ;  Hee Rim Nam  ;  Ki Chang Keum  ;  Chang Ok Suh  ;  Yong Bae Kim 
Citation
 RADIATION ONCOLOGY JOURNAL, Vol.32(3) : 132-137, 2014 
Journal Title
 RADIATION ONCOLOGY JOURNAL 
ISSN
 2234-1900 
Issue Date
2014
Keywords
Axillary lymph node dissection ; Breast neoplasms ; Local ; Neoplasm recurrence ; Sentinel lymph node biopsy
Abstract
PURPOSE: To evaluate non-sentinel lymph node (LN) status after sentinel lymph node biopsy (SNB) in patients with breast cancer and to identify the predictive factors for disease failure. MATERIALS AND METHODS: From January 2006 to December 2007, axillary lymph node (ALN) dissection after SNB was performed for patients with primary invasive breast cancer who had no clinical evidence of LN metastasis. A total of 320 patients were treated with breast-conserving surgery and radiotherapy. RESULTS: The median age of patients was 48 years, and the median follow-up time was 72.8 months. Close resection margin (RM) was observed in 13 patients. The median number of dissected SNB was two, and that of total retrieved ALNs was 11. Sentinel node accuracy was 94.7%, and the overall false negative rate (FNR) was 5.3%. Eleven patients experienced treatment failure. Local recurrence, regional LN recurrence, and distant metastasis were identified in 0.9%, 1.9%, and 2.8% of these patients, respectively. Sentinel LN status were not associated with locoregional recurrence (p > 0.05). Close RM was the only significant factor for disease-free survival (DFS) in univariate and multivariate analysis. The 5-year overall survival, DFS, and locoregional DFS were 100%, 96.8%, and 98.1%, respectively. CONCLUSION: In this study, SNB was performed with high accuracy and low FNR and high locoregional control was achieved.
Files in This Item:
T201403413.pdf Download
DOI
10.3857/roj.2014.32.3.132
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Keum, Ki Chang(금기창) ORCID logo https://orcid.org/0000-0003-4123-7998
Kim, Yong Bae(김용배) ORCID logo https://orcid.org/0000-0001-7573-6862
Suh, Chang Ok(서창옥)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99918
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