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In-Vitro Stem Cell Derived Red Blood Cells for Transfusion: Are We There Yet?

Authors
 Hyun Ok Kim 
Citation
 YONSEI MEDICAL JOURNAL, Vol.55(2) : 304-309, 2014 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2014
MeSH
Antigens, CD34/metabolism ; Blood Transfusion/methods* ; Cell Culture Techniques ; Erythrocytes*/cytology ; Erythrocytes*/physiology ; Erythropoiesis ; Fetal Blood/cytology ; Humans ; Stem Cells/cytology* ; Stem Cells/physiology*
Keywords
CD34+ cell ; erythroid culture ; in vitro RBC production
Abstract
To date, the use of red blood cells (RBCs) produced from stem cells in vitro has not proved practical for routine transfusion. However, the perpetual and widespread shortage of blood products, problems related to transfusion-transmitted infections, and new emerging pathogens elicit an increasing demand for artificial blood. Worldwide efforts to achieve the goal of RBC production through stem cell research have received vast attention; however, problems with large-scale production and cost effectiveness have yet to prove practical usefulness. Some progress has been made, though, as cord blood stem cells and embryonic stem cells have shown an ability to differentiate and proliferate, and induced pluripotent stem cells have been shown to be an unlimited source for RBC production. However, transfusion of stem cell-derived RBCs still presents a number of challenges to overcome. This paper will summarize an up to date account of research and advances in stem cell-derived RBCs, delineate our laboratory protocol in producing RBCs from cord blood, and introduce the technological developments and limitations to current RBC production practices.
Files in This Item:
T201403358.pdf Download
DOI
10.3349/ymj.2014.55.2.304
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99893
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