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The role of metabolic tumor volume and total lesion glycolysis on 18F-FDG PET/CT in the prognosis of epithelial ovarian cancer

Authors
 Jeong Won Lee  ;  Arthur Cho  ;  Jae-Hoon Lee  ;  Mijin Yun  ;  Jong Doo Lee  ;  Young Tae Kim  ;  Won Jun Kang 
Citation
 EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.41(10) : 1898-1906, 2014 
Journal Title
 EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 
ISSN
 1619-7070 
Issue Date
2014
MeSH
Adult ; Aged ; Carcinoma/diagnostic imaging* ; Carcinoma/metabolism ; Female ; Fluorodeoxyglucose F18 ; Glycolysis* ; Humans ; Middle Aged ; Multimodal Imaging* ; Ovarian Neoplasms/diagnostic imaging* ; Ovarian Neoplasms/metabolism ; Positron-Emission Tomography* ; Prognosis ; Radiopharmaceuticals ; Tomography, X-Ray Computed*
Keywords
Ovarian cancer ; 18F-fluorodeoxyglucose PET ; Metabolic tumor volume ; Total lesion glycolysis ; Prognosis
Abstract
PURPOSE: This study assessed the prognostic value of pre-operative 2-[(18)F] fluoro-2-deoxy-D-glucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) volumetric parameters, including metabolic tumor volume (MTV) and total lesion glycolysis (TLG), in patients with epithelial ovarian cancer. METHODS: A total of 175 patients with epithelial ovarian cancer who underwent (18) F-FDG PET/CT and subsequent cytoreductive surgery were retrospectively enrolled. Maximum standardized uptake value (SUVmax) on (18)F-FDG PET/CT was measured for all patients. Because nine patients showed low tumor-to-background uptake ratios, MTV and TLG were measured in 166 patients. Univariate and multivariate analyses were performed to evaluate the prognostic significance of SUVmax, MTV, TLG, and clinicopathological factors for disease progression-free survival. RESULTS: Disease progressed in 78 (44.6 %) of the 175 patients, and the 2-year disease progression-free survival rate was 57.5 %. Univariate analysis showed that tumor stage, histopathological type, presence of regional lymph node metastasis, residual tumor after cytoreductive surgery, pre-operative serum carbohydrate antigen 125 (CA125) level, SUVmax, MTV, and TLG were significant prognostic factors (p < 0.05). Among these variables, tumor stage (p = 0.0006) and TLG (p = 0.008) independently correlated with disease progression-free survival on multivariate analysis. The disease progression rate was only 2.3 % in stage I-II patients with low TLG (≤100.0), compared to 80.0 % in stage III-IV patients with high TLG (>100.0). CONCLUSION: Along with tumor stage, TLG is an independent prognostic factor for disease progression after cytoreductive surgery in patients with epithelial ovarian cancer. By combining tumor stage and TLG, one can further stratify the risk of disease progression for patients undergoing cytoreductive surgery.
Full Text
http://link.springer.com/article/10.1007%2Fs00259-014-2803-x
DOI
10.1007/s00259-014-2803-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Won Jun(강원준) ORCID logo https://orcid.org/0000-0002-2107-8160
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0002-9898-9886
Lee, Jeong Won(이정원)
Lee, Jong Doo(이종두)
Cho, Arthur Eung Hyuck(조응혁) ORCID logo https://orcid.org/0000-0001-8670-2473
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99860
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