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Induced pluripotent stem cells for modeling of pediatric neurological disorders

DC FieldValueLanguage
dc.contributor.author강훈철-
dc.contributor.author백선열-
dc.contributor.author송효숙-
dc.contributor.author염윤진-
dc.contributor.author장지호-
dc.date.accessioned2015-01-06T17:21:54Z-
dc.date.available2015-01-06T17:21:54Z-
dc.date.issued2014-
dc.identifier.issn1860-6768-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99841-
dc.description.abstractThe pathophysiological mechanisms underlying childhood neurological disorders have remained obscure due to a lack of suitable disease models reflecting human pathogenesis. Using induced pluripotent stem cell (iPSC) technology, various neurological disorders can now be extensively modeled. Specifically, iPSC technology has aided the study and treatment of early-onset pediatric neurodegenerative diseases such as Rett syndrome, Down syndrome, Angelman syndrome. Prader–Willi syndrome, Friedreich's ataxia, spinal muscular atrophy (SMA), fragile X syndrome, X-linked adrenoleukodystrophy (ALD), and SCN1A gene-related epilepsies. In this paper, we provide an overview of various gene delivery systems for generating iPSCs, the current state of modeling early-onset neurological disorders and the ultimate application of these in vitro models in cell therapy through the correction of disease-specific mutations.-
dc.description.statementOfResponsibilityopen-
dc.format.extent871~881-
dc.relation.isPartOfBIOTECHNOLOGY JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHChild-
dc.subject.MESHChild Development/physiology-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHHumans-
dc.subject.MESHInduced Pluripotent Stem Cells/cytology*-
dc.subject.MESHModels, Neurological-
dc.subject.MESHNervous System Diseases/therapy*-
dc.subject.MESHNeurodegenerative Diseases/therapy*-
dc.titleInduced pluripotent stem cells for modeling of pediatric neurological disorders-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorJiho Jang-
dc.contributor.googleauthorZhejiu Quan-
dc.contributor.googleauthorYunjin J. Yum-
dc.contributor.googleauthorHyo Sook Song-
dc.contributor.googleauthorSeonyeol Paek-
dc.contributor.googleauthorHoon-Chul Kang-
dc.identifier.doi10.1002/biot.201400010-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00102-
dc.contributor.localIdA01819-
dc.contributor.localIdA02081-
dc.contributor.localIdA02351-
dc.contributor.localIdA03480-
dc.relation.journalcodeJ00335-
dc.identifier.eissn1860-7314-
dc.identifier.pmid24838856-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/biot.201400010/abstract-
dc.subject.keywordCell-based therapy-
dc.subject.keywordDisease modeling-
dc.subject.keywordDrug screening-
dc.subject.keywordInduced pluripotent stem cells-
dc.subject.keywordPediatric neurological disorders-
dc.contributor.alternativeNameKang, Hoon Chul-
dc.contributor.alternativeNamePaek, Seon Yeol-
dc.contributor.alternativeNameSong, Hyo Sook-
dc.contributor.alternativeNameYum, Yunjin J.-
dc.contributor.alternativeNameJang, Ji Ho-
dc.contributor.affiliatedAuthorKang, Hoon Chul-
dc.contributor.affiliatedAuthorPaek, Seon Yeol-
dc.contributor.affiliatedAuthorSong, Hyo Sook-
dc.contributor.affiliatedAuthorYum, Yunjin J.-
dc.contributor.affiliatedAuthorJang, Ji Ho-
dc.rights.accessRightsfree-
dc.citation.volume9-
dc.citation.number7-
dc.citation.startPage871-
dc.citation.endPage881-
dc.identifier.bibliographicCitationBIOTECHNOLOGY JOURNAL, Vol.9(7) : 871-881, 2014-
dc.identifier.rimsid53832-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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