Cited 6 times in
Postoperative adjuvant chemoradiotherapy in D2-dissected gastric cancer: Is radiotherapy necessary after D2-dissection?
DC Field | Value | Language |
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dc.contributor.author | 금웅섭 | - |
dc.contributor.author | 윤홍인 | - |
dc.contributor.author | 장지석 | - |
dc.date.accessioned | 2015-01-06T17:20:32Z | - |
dc.date.available | 2015-01-06T17:20:32Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99799 | - |
dc.description.abstract | Studies from the Far East have demonstrated that D2-dissection is superior to D0/1-dissection. The effect of postoperative chemoradiotherapy (CRT) after D2-dissection has not been accepted due to the lack of D2-dissection in Western countries, as well as the potential harmful effect of radiotherapy. In the current NCCN guideline, adjuvant chemotherapy alone is recommended in D2-dissected patients. However, three recent prospective randomized controlled trials in South Korea and China (ARTIST, NCC and Multicenter IMRT Trials) demonstrated that adjuvant CRT can be safely administered to D2-dissected patients with notable benefits. To identify the role of radiotherapy (RT) in the D2-dissected postoperative setting, clinical research attempts should include (1) identification of high-risk patients for loco-regional recurrence who might benefit from CRT; (2) modification of RT target volume based on the findings that failure patterns should be different after D1- and D2-dissection; and (3) integration of new RT techniques to decrease treatment-related toxicity. The present paper is a review of recent studies addressing these fields. Well-designed prospective randomized studies are needed to clearly define the role of adjuvant CRT in D2-dissected gastric cancer, however, future clinical studies should also focus on answering these questions. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 12900~12907 | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Chemoradiotherapy, Adjuvant*/adverse effects | - |
dc.subject.MESH | Chemoradiotherapy, Adjuvant*/mortality | - |
dc.subject.MESH | Gastrectomy*/adverse effects | - |
dc.subject.MESH | Gastrectomy*/mortality | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymph Node Excision*/adverse effects | - |
dc.subject.MESH | Lymph Node Excision*/mortality | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Patient Selection | - |
dc.subject.MESH | Radiotherapy, Adjuvant | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Stomach Neoplasms/mortality | - |
dc.subject.MESH | Stomach Neoplasms/pathology | - |
dc.subject.MESH | Stomach Neoplasms/therapy* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Postoperative adjuvant chemoradiotherapy in D2-dissected gastric cancer: Is radiotherapy necessary after D2-dissection? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Jee Suk Chang | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.contributor.googleauthor | Youngin Lee | - |
dc.contributor.googleauthor | Hong In Yoon | - |
dc.contributor.googleauthor | Hyung Sik Lee | - |
dc.identifier.doi | 10.3748/wjg.v20.i36.12900 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00273 | - |
dc.contributor.localId | A04777 | - |
dc.contributor.localId | A04658 | - |
dc.relation.journalcode | J02795 | - |
dc.identifier.eissn | 2219-2840 | - |
dc.identifier.pmid | 25278687 | - |
dc.subject.keyword | Chemotherapy | - |
dc.subject.keyword | D2-dissection | - |
dc.subject.keyword | Gastric cancer | - |
dc.subject.keyword | Radiotherapy | - |
dc.subject.keyword | Recurrence | - |
dc.contributor.alternativeName | Koom, Woong Sub | - |
dc.contributor.alternativeName | Yoon, Hong In | - |
dc.contributor.affiliatedAuthor | Koom, Woong Sub | - |
dc.contributor.affiliatedAuthor | Yoon, Hong In | - |
dc.citation.volume | 20 | - |
dc.citation.number | 36 | - |
dc.citation.startPage | 12900 | - |
dc.citation.endPage | 12907 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROENTEROLOGY, Vol.20(36) : 12900-12907, 2014 | - |
dc.identifier.rimsid | 49607 | - |
dc.type.rims | ART | - |
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