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Neural basis of anhedonia as a failure to predict pleasantness in schizophrenia

Authors
 Soo-Hee Choi  ;  Hyeongrae Lee  ;  Jeonghun Ku  ;  Kang Joon Yoon  ;  Jae-Jin Kim 
Citation
 WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, Vol.15(7) : 525-533, 2014 
Journal Title
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
ISSN
 1562-2975 
Issue Date
2014
MeSH
Adult ; Anhedonia/physiology* ; Anticipation, Psychological/physiology* ; Caudate Nucleus/physiopathology* ; Female ; Gyrus Cinguli/physiopathology* ; Humans ; Magnetic Resonance Imaging ; Male ; Prefrontal Cortex/physiopathology* ; Schizophrenia/physiopathology* ; Young Adult
Keywords
Schizophrenia ; anhedonia ; anterior cingulate cortex ; anticipatory pleasure ; caudate
Abstract
OBJECTIVES: Anhedonia in schizophrenia results from a deficit in anticipatory pleasure rather than consummatory pleasure. This study aimed to determine the neural basis of the predictive and experiential components of anticipatory pleasure in schizophrenia. METHODS: A hedonic rating task was performed by 15 patients with schizophrenia and 17 controls while undergoing functional magnetic resonance imaging. Participants evaluated the level of pleasantness for the preview/predictive phase, comprising a narration and adjunctive audiovisual stimuli for pleasurable experience, and the subsequent viewing/experiential phase, comprising a video clip for a pleasant event. RESULTS: A significant group-by-phase interaction was seen in the rostral anterior cingulate cortex (ACC) and caudate, resulting from reduced activations in patients during the preview phase. Patients showed significantly reduced activation in the frontopolar cortex and rostral ACC during the preview phase. The signal changes in the caudate and frontopolar cortex were associated with increase in hedonic response during the sequential pleasure experiences. CONCLUSIONS: Augmentation of hedonic enjoyment between the predictive and experiential stages of anticipatory pleasure is reduced in schizophrenia because of diminished activity in the reward-related regions during the prediction of pleasure. During cued-emotional experiences of anticipatory pleasure, patients seem to have difficulties in the integration of emotional information.
Full Text
http://informahealthcare.com/doi/abs/10.3109/15622975.2013.819121
DOI
10.3109/15622975.2013.819121
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99776
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