Cited 6 times in
Sex-Related Differences in the Effect-Site Concentration of Remifentanil for Preventing QTc Interval Prolongation Following Intubation in Elderly Patients with a Normal QTc Interval
DC Field | Value | Language |
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dc.contributor.author | 김민수 | - |
dc.contributor.author | 김소연 | - |
dc.contributor.author | 송미경 | - |
dc.contributor.author | 한동우 | - |
dc.date.accessioned | 2015-01-06T17:14:31Z | - |
dc.date.available | 2015-01-06T17:14:31Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1170-229X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99604 | - |
dc.description.abstract | BACKGROUND: Female sex and age more than 65 years are common risk factors for the development of torsades de pointes in association with heart rate-corrected QT (QTc) interval prolongation, which can be induced by tracheal intubation during general anaesthesia. However, the administration of remifentanil can prevent intubation-induced QTc interval prolongation. We compared sex-related differences in the effect-site concentration (Ce) of remifentanil for preventing QTc interval prolongation among elderly patients. METHODS: Twenty-two female and 22 male patients older than 65 years were enrolled. Anaesthesia was induced with remifentanil and propofol using a target-controlled infusion. The Ce of remifentanil for maintaining a QTc interval prolongation <15 ms following intubation was determined for each sex using the isotonic regression method and a bootstrapping approach following Dixon's up-and-down method. RESULTS: The Ce of remifentanil for preventing QTc interval prolongation following intubation in 50 % of the population (EC50) and 95 % of the population (EC95) were significantly lower in females than in males. Isotonic regression revealed that the EC50 (83 % confidence interval) of remifentanil was 3.50 (2.95-4.08) ng/mL in females and 4.38 (4.08-4.63) ng/mL in males. The EC95 (95 % confidence interval) of remifentanil was 4.43 (4.25-4.48) ng/mL in females and 4.94 (4.78-4.98) ng/mL in males. CONCLUSIONS: Target-controlled infusion of remifentanil is effective in attenuating QTc interval prolongation after intubation among elderly patients and the Ce of remifentanil is lower in females than in males. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 695~702 | - |
dc.relation.isPartOf | DRUGS & AGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Anesthesia, General/adverse effects | - |
dc.subject.MESH | Anesthetics, Intravenous/administration & dosage* | - |
dc.subject.MESH | Anesthetics, Intravenous/pharmacology | - |
dc.subject.MESH | Arrhythmias, Cardiac/prevention & control* | - |
dc.subject.MESH | Drug Administration Schedule | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Health Services for the Aged | - |
dc.subject.MESH | Heart Conduction System/drug effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inhibitory Concentration 50 | - |
dc.subject.MESH | Intubation, Intratracheal/adverse effects | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Piperidines/administration & dosage* | - |
dc.subject.MESH | Piperidines/pharmacology | - |
dc.subject.MESH | Postoperative Complications/prevention & control* | - |
dc.subject.MESH | Propofol/administration & dosage | - |
dc.subject.MESH | Sex Factors | - |
dc.title | Sex-Related Differences in the Effect-Site Concentration of Remifentanil for Preventing QTc Interval Prolongation Following Intubation in Elderly Patients with a Normal QTc Interval | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | S. Y. Kim | - |
dc.contributor.googleauthor | M. K. Song | - |
dc.contributor.googleauthor | M.-S. Kim | - |
dc.contributor.googleauthor | E. H. Kim | - |
dc.contributor.googleauthor | D. W. Han | - |
dc.identifier.doi | 10.1007/s40266-014-0198-9 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02020 | - |
dc.contributor.localId | A04274 | - |
dc.contributor.localId | A00463 | - |
dc.contributor.localId | A00616 | - |
dc.relation.journalcode | J00751 | - |
dc.identifier.eissn | 1179-1969 | - |
dc.identifier.pmid | 24989629 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs40266-014-0198-9 | - |
dc.subject.keyword | Mean Arterial Pressure | - |
dc.subject.keyword | Tracheal Intubation | - |
dc.subject.keyword | Remifentanil | - |
dc.subject.keyword | Ephedrine | - |
dc.subject.keyword | Cardiac Repolarisation | - |
dc.contributor.alternativeName | Kim, Min Soo | - |
dc.contributor.alternativeName | Kim, So Yeon | - |
dc.contributor.alternativeName | Song, Mi Kyung | - |
dc.contributor.alternativeName | Han, Dong Woo | - |
dc.contributor.affiliatedAuthor | Song, Mi Kyung | - |
dc.contributor.affiliatedAuthor | Han, Dong Woo | - |
dc.contributor.affiliatedAuthor | Kim, Min Soo | - |
dc.contributor.affiliatedAuthor | Kim, So Yeon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 31 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 695 | - |
dc.citation.endPage | 702 | - |
dc.identifier.bibliographicCitation | DRUGS & AGING, Vol.31(9) : 695-702, 2014 | - |
dc.identifier.rimsid | 38947 | - |
dc.type.rims | ART | - |
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