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Tumour size is related to the curability of signet ring cell early gastric cancer with endoscopic submucosal dissection: A retrospective single centre study

Authors
 Mi Na Kim  ;  Hyun Ki Kim  ;  Choong Nam Shim  ;  Hyun Jik Lee  ;  Hyuk Lee  ;  Jun Chul Park  ;  Sung Kwan Shin  ;  Sang Kil Lee  ;  Yong Chan Lee 
Citation
 DIGESTIVE AND LIVER DISEASE, Vol.46(10) : 898-902, 2014 
Journal Title
 DIGESTIVE AND LIVER DISEASE 
ISSN
 1590-8658 
Issue Date
2014
MeSH
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Signet Ring Cell/pathology ; Carcinoma, Signet Ring Cell/surgery* ; Dissection/methods* ; Female ; Gastric Mucosa/pathology ; Gastric Mucosa/surgery* ; Gastroscopy/methods* ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Regression Analysis ; Retrospective Studies ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery* ; Treatment Outcome ; Tumor Burden*
Keywords
Curability ; Early gastric cancer ; Endoscopic submucosal dissection ; Signet ring cell carcinoma ; Tumour size
Abstract
BACKGROUND: Endoscopic submucosal dissection is applied in selected cases of signet ring cell early gastric cancer. However, factors related to curability of signet ring cell early gastric cancer with this method have not been fully evaluated. Our aim was to evaluate factors related to incomplete resection in signet ring cell early gastric cancer with endoscopic submucosal dissection. METHODS: A retrospective analysis was performed on a total of 126 consecutive patients with signet ring cell early gastric cancer who had undergone endoscopic submucosal dissection at the Severance Hospital in Korea, between March 2007 and March 2012. The clinical outcomes were reviewed and factors related to incomplete resection were analysed. RESULTS: Multivariate analysis showed that large tumour size was the only significant factor related to incomplete resection (P=0.006; hazard ratio, 1.040; 95% confidence interval, 1.101-1.084). In addition, large tumour size was the only significant factor related to endoscopic size underestimation (P<0.001; hazard ratio, 1.391; 95% confidence interval, 1.221-1.586). The rate of endoscopic size underestimation was significantly higher in tumours with a size ≥20mm (P<0.001). CONCLUSIONS: To improve the curability of signet ring cell early gastric cancer with endoscopic submucosal dissection, larger tumours (especially tumour with a size ≥20mm) should be resected with a larger margin.
Full Text
http://www.sciencedirect.com/science/article/pii/S1590865814003776
DOI
10.1016/j.dld.2014.05.019
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Mi Na(김미나)
Kim, Hyunki(김현기) ORCID logo https://orcid.org/0000-0003-2292-5584
Park, Jun Chul(박준철) ORCID logo https://orcid.org/0000-0001-8018-0010
Shin, Sung Kwan(신성관) ORCID logo https://orcid.org/0000-0001-5466-1400
Shim, Choong Nam(심충남)
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
Lee, Hyuk(이혁)
Lee, Hyun Jik(이현직)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99598
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